Lectures in course CH-411: Cellular signalling

Cellular Signalling: Introduction & Mechanisms Log in to Mediaspace to watch this video

Covers cellular signalling, including long-distance communication, receptor mechanisms, and the impact of small numbers in biology.

Receptor-Ligand Interaction Log in to Mediaspace to watch this video

Explores receptor-ligand interactions, covering binding, dissociation, equilibrium, and quantification methods.

Ligand-gated Ion Channels: Mechanisms and Models Log in to Mediaspace to watch this video

Explores experimental approaches and models of ligand-gated ion channels, including the effects of nicotine.

Nicotinic Receptors: Structure and Function Log in to Mediaspace to watch this video

Explores the structure and function of nicotinic receptors, focusing on Cys-loop receptors, ion conductance, and the effects of nicotine.

G Protein-Coupled Receptors: Structure and Signalling Log in to Mediaspace to watch this video

Explores the structure, signalling, and drug targeting of G protein-coupled receptors, emphasizing their importance in pharmaceutical research.

G Protein-Coupled Receptors: Basics and Structures Log in to Mediaspace to watch this video

Explores the basics and structures of G protein-coupled receptors, covering signaling schemes, structures, historical background, drug targeting, and recent advancements.

G Protein-Coupled Receptors: Signalling Diversity and Complexity Log in to Mediaspace to watch this video

Explores the diversity and complexity of G protein-coupled receptors, focusing on their signalling pathways, ligand effects, and cellular activity.

G Protein-Coupled Receptors: Signalling Diversity Log in to Mediaspace to watch this video

Explores G protein-coupled receptors' signalling diversity, covering structure, activation, bias effects, and internalisation.

TRP Channels: Sensory Perception Log in to Mediaspace to watch this video

Explores TRP ion channels' role in sensory perception of heat, cold, and pain, modulation by various stimuli, and involvement in nociception and mechanosensation.

TRP Channels: Structure and Function Log in to Mediaspace to watch this video

Explores the structure and function of TRP channels in temperature and pain perception, covering topics such as activation by capsaicin and modulation of channel currents.

TRP Channels: Sensory Perception Log in to Mediaspace to watch this video

Explores TRP channels' role in sensory perception, focusing on their activation by various stimuli and their implications in disease pathogenesis.

Receptor Tyrosine Kinases: Signalling and Regulation Log in to Mediaspace to watch this video

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Receptor-Ligand Interaction: Quantification and Mechanisms Log in to Mediaspace to watch this video

Explores methods to quantify receptor-ligand interactions, ligand-gated ion channels, and the Hill equation.

Nuclear Receptors: Signalling and Health Implications Log in to Mediaspace to watch this video

Explores nuclear receptors, JAK-STAT pathway, growth factors, endocrine disruptors, and estrogen receptors.

Nuclear Receptors: Core Signaling Log in to Mediaspace to watch this video

Explores nuclear receptors' core signaling and the impact of endocrine disruptors on the endocrine system, including the inhibitory effects of compounds like eugenol on the estrogen receptor.

Protein Domains & Interactions Log in to Mediaspace to watch this video

Explores protein interactions, domains, scaffolds, and signaling networks in cellular biology.

Membrane Binding Domains: PIP Signaling Pathway Log in to Mediaspace to watch this video

Explores the role of membrane binding domains in the PIP signaling pathway and the recognition of PIPx species by specific domains.

Protein Interactions & Membrane Binding Log in to Mediaspace to watch this video

Explores protein interactions, membrane binding, scaffolds, effective molarity, and genome-wide approaches in studying protein interactions.

Protein Lipidation: Membrane Localization and Signalling Log in to Mediaspace to watch this video

Covers protein lipidation, membrane localization, major lipid classes, signaling modulation, and lipid rafts in biological membranes.

Protein Lipidation: Membrane Organization Log in to Mediaspace to watch this video

Explores protein lipidation, membrane localisation, lipid modification impact on signalling, and dynamic lipidation processes.