Lecture

Protein Interactions & Membrane Binding

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In course

CH-411: Cellular signalling

Presentation of selected signalling pathways with emphasis on both the mechanism of action of the molecules involved, molecular interactions and the role of their spatio-temporal organization within the cell, considering cellular dimensions and conditions. ...

Description

This lecture covers the domains involved in protein interactions and membrane binding, focusing on lipid-binding domains and scaffolds enabling protein interactions. It discusses the importance of protein-protein interactions in cellular organization, the role of scaffolds in bringing proteins together, and the manipulation of protein location and activation. The instructor explains the concept of effective molarity and how scaffolds enhance local concentrations, leading to accelerated chemical kinetics. The lecture also delves into genome-wide approaches to studying protein interactions, the specificity of protein domains, and the significance of poly-pharmacology in drug development.

Instructor

Rudolf Hovius

Expertise Â•Protein structure, expression & purificationÂ•Molecular interaction & receptor activationÂ•Fluorescence imaging & spectroscopySignalling & sensing Mission => Teaching: Lecture courses, tutorials and practicals in biochemistry, biophysical chemistry of membranes and signalling processes. Participating to the Commission d'Enseignement and Commission de l'Ecole Doctorale of Chemistry and Chemical Engineering.=> Research interests: Protein function and structure, Membrane protein (especially recepto

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