Lecture

TRP Channels: Sensory Perception

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In course

CH-411: Cellular signalling

Presentation of selected signalling pathways with emphasis on both the mechanism of action of the molecules involved, molecular interactions and the role of their spatio-temporal organization within the cell, considering cellular dimensions and conditions. ...

Description

This lecture explores the transient receptor potential (TRP) ion channels, focusing on their role in sensory perception of heat, cold, and pain. It covers the structure, activation, and physiological functions of TRP channels, including TRPV1 and TRPM8. The lecture delves into the modulation of TRP channels by various stimuli, such as temperature, chemicals, and membrane potential. Additionally, it discusses the covalent activation of TRPA1 by pungent compounds and the involvement of TRP channels in mechanisms like nociception and cold perception. The presentation also touches on TRP channels' role in mechanosensation, particularly in hearing in Drosophila.

Instructor

Rudolf Hovius

Expertise Â•Protein structure, expression & purificationÂ•Molecular interaction & receptor activationÂ•Fluorescence imaging & spectroscopySignalling & sensing Mission => Teaching: Lecture courses, tutorials and practicals in biochemistry, biophysical chemistry of membranes and signalling processes. Participating to the Commission d'Enseignement and Commission de l'Ecole Doctorale of Chemistry and Chemical Engineering.=> Research interests: Protein function and structure, Membrane protein (especially recepto

Official source

Related concepts (32)

Sense

A sense is a biological system used by an organism for sensation, the process of gathering information about the world through the detection of stimuli. Although in some cultures five human senses were traditionally identified as such (namely sight, smell, touch, taste, and hearing), it is now recognized that there are many more. Senses used by non-human organisms are even greater in variety and number. During sensation, sense organs collect various stimuli (such as a sound or smell) for transduction, meaning transformation into a form that can be understood by the brain.

Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters.

Pain

Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Pain motivates organisms to withdraw from damaging situations, to protect a damaged body part while it heals, and to avoid similar experiences in the future.

Modulation

In electronics and telecommunications, modulation is the process of varying one or more properties of a periodic waveform, called the carrier signal, with a separate signal called the modulation signal that typically contains information to be transmitted. For example, the modulation signal might be an audio signal representing sound from a microphone, a video signal representing moving images from a video camera, or a digital signal representing a sequence of binary digits, a bitstream from a computer.

Heat

In thermodynamics, heat is the thermal energy transferred between systems due to a temperature difference. In colloquial use, heat sometimes refers to thermal energy itself. An example of formal vs. informal usage may be obtained from the right-hand photo, in which the metal bar is "conducting heat" from its hot end to its cold end, but if the metal bar is considered a thermodynamic system, then the energy flowing within the metal bar is called internal energy, not heat.

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