Course

CH-332: Medicinal chemistry

Summary

This course introduces medicinal chemistry: how small molecules are designed and optimised to become medicines, covering principles of molecular recognition, pharmacokinetics, and drug design alongside selected therapeutic examples and emerging modalities.

Lectures

Instructors

Official source

https://edu.epfl.ch/coursebook/en/medicinal-chemistry-CH-332

Moodle Page

http://go.epfl.ch/CH-332

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Summary

Lectures

Instructors

Official source

https://edu.epfl.ch/coursebook/en/medicinal-chemistry-CH-332

Moodle Page

http://go.epfl.ch/CH-332

About this result

Lectures in this course (12)

Identifying Drug Targets: Safety and Efficacy

Delves into identifying drug targets, ensuring efficacy, and maintaining safety in medical chemistry, covering genetic tests, chirality, stereochemistry, drug resistance, and drug-likeness rules.

Interrogating SAR in Medical Chemistry

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Preclinical Animal Models: Selection & Rationale

Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.

Fragment-Based Drug Discovery: Concepts & Technologies

Covers the concepts and technologies of fragment-based drug discovery, exploring hit identification, lead optimization, and screening methods.

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