Course

BIOENG-320: Synthetic biology

Summary

This advanced Bachelor/Master level course will cover fundamentals and approaches at the interface of biology, chemistry, engineering and computer science for diverse fields of synthetic biology. This class requires critical and analytical thinking at the frontiers of multiple disciplines

Lectures

Instructor

Patrick Daniel Barth

Professor Patrick Barth is Associate Professor at EPFL and Adjunct Associate Professor at Baylor College of Medicine, Houston, TX, USA. He received training in Physics, Chemistry and Biology (University of Paris, ENS) in France and performed his PhD at the Commissiariat a l'Energie Atomique in Saclay, France on structure/function studies of membrane proteins (photosystem I) using biochemical and biophysical experimental techniques. He carried out postdoctoral studies at University of California at Berkeley with Tom Alber on computational development for calculating protein electrostatics and designing de novo selective peptide inhibitors of cellular protein interactions. He then went to the University of Washington as a postdoctoral fellow and instructor in David Baker's laboratory to develop computational techniques in the software Rosetta for predicting and designing membrane protein structures. He started his independent career and received tenure at Baylor College of Medicine. He will continue at EPFL to marry computation and experiment for understanding the molecular determinants of signal transduction, as well as modeling and designing membrane proteins with novel functions for various synthetic biology and therapeutic applications.

Official source

https://edu.epfl.ch/coursebook/en/synthetic-biology-BIOENG-320

Moodle Page

http://go.epfl.ch/BIOENG-320

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Summary

Lectures

Instructor

Patrick Daniel Barth

Official source

https://edu.epfl.ch/coursebook/en/synthetic-biology-BIOENG-320

Moodle Page

http://go.epfl.ch/BIOENG-320

Lectures in this course (30)

Protein Design: Structure and Function Log in to Mediaspace to watch this video

Explores protein design challenges, validation through crystallography, evolution of design techniques, and the difference between genetic and protein circuits.

Genetic Circuits: Synthetic Biology Log in to Mediaspace to watch this video

Covers genetic circuits in synthetic biology, including metabolic engineering, lac operon regulation, and synthetic circuit design.

Engineering Intelligent Cells Log in to Mediaspace to watch this video

Explores engineering intelligent cells through genetic and protein circuits for cell engineering, discussing sensing mechanisms and signal transmission.

Synthetic Biology Standardization Log in to Mediaspace to watch this video

Emphasizes standardization in Synthetic Biology, logic rules, chassis cells, and metabolic engineering transition.

Protein Circuit Design: Signal Transmission and Dynamic Control Log in to Mediaspace to watch this video

Explores protein-mediated signal transmission, dynamic control, logic operations, and cell-based therapeutics.

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