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Drugs for Neglected Diseases Initiative

Related publications (18)

Investigating the analytical robustness of the social and behavioural sciences

The same dataset can be analysed in different justifiable ways to answer the same research question, potentially challenging the robustness of empirical science. In this crowd initiative, we investigated the degree to which research findings in the social and behavioural sciences are contingent on analysts’ choices. We examined a stratified random sample of 100 studies published between 2009 and 2018, in which, for one claim per study, at least five reanalysts independently reanalysed the original data. The

Nature Research2026

Reclaiming the Village: a Prototype for Rural Renewal in Polish Galicia

The project builds on the theoretical statement regarding the neglected development of rural Poland, where political disturbance and historical fragmentation have led to uneven infrastructure, lack of progress, and a chaotic architectural landscape. This project responds to those issues by reimaging the relationship between architecture and the rural community. Focused on a small village in Polish Galicia, it proposes strategic interventions: replacing polluting factory with a cider plant that merges habita

EPFL2025

Systems and methods for treating excess pressure having an elastic membrane in fluid contact with bodily fluid

Nikolaos Stergiopoulos

Systems and methods are provided for treating diseases that produce elevated pressure, e.g., intraocular pressure or cerebrospinal fluid pressure, such as glaucoma or hydrocephalus, wherein the device includes a housing shell, an elastic membrane, and a local constriction that reduces the area of the fluidic passageway through the housing shell and increases fluidic resistance of the flow of fluid through the passageway. At normal IOP levels, the elastic membrane engages the local constriction to prevent or

2025

Ukrainian core cities: navigating between decentralisation, metropolisation, and wartime challenges

The proliferation of dispersed and fragmented urban forms and extended urbanization processes in Europe has been continuously challenging the established administrative borders and governance models (Robinson & Le Galès 2024, 10). In this context, the issue of institutional fragmentation of a city-region, defined morphologically, functionally, economically, or epistemologically, comes to the forefront. It is addressed by specific state strategies and policies that open up new territories for urbanisation (T

2024

Mega Event Reinforced Industrial Heritage Transformation: A typological matrix between narratives and practices

Mega-events have been considered as a strategy to boost urban development, which shifts targets from expansion outside of the original city fabric to reuse of heritage. The bidirectional dynamic between mega-events and heritage has been emphasized, as the former brings both resources and contradiction, and nowadays, the latter is further exploited for future development, connecting its value with the need of society. However, the research on the coupling between mega-events and industrial heritage, as a cru

2022

SWEDISH GRACE: A MERE INTERLUDE OR A FACET OF MODERNITY? First housing experiments in Stockholm

Sweden forms a strange case in the modern development, which this paper aims to examine in detail through the first housing district experiments in Stockholm. Its position on the fringe of the radical ferment of Europe implied a belated advent of modernism in what some prominent critics see through a monolithic viewpoint, such as a homogenizing viewpoint of modernism. When European avant-garde gradually began to decline, functionalism (playfully nicknamed Funkis by the Swedish press) was born in Sweden, an

2019

Apparatus and methods for treating excess intraocular fluid

Nikolaos Stergiopoulos, Stéphane Bigler

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adju ...

2017

Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

Romain Hamelin, Sandrine Madeleine Suzanne Georgeon, Oliver Hantschel, Sina Maren Reckel

The two major isoforms of the oncogenic Bcr-Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p190 occurs in the majority of B-cell acute lymphobl ...

Nature Publishing Group2017

Can medical products be developed on a non-profit basis? Exploring product development partnerships for neglected diseases

Dominique Foray, Fabiana Visentin, Patrick Gaulé, Viviana Carolina Munoz Tellez de Kieffer

Reliance on market forces can lead to underinvestment in social welfare enhancing innovation. The lack of new medical products in the area of neglected diseases is a case in point. R&D for neglected diseases has increased with new funding and collaboration ...

Oxford University Press2015

Geostatistical modelling for the monitoring of environmental-related endemic diseases: Application to the distribution of schistosomiasis in Burkina Faso

The increased interest of reducing the infection rates of neglected tropical diseases like schistosomiasis in the world has raised the necessity of developing epidemiological monitoring techniques, in order to target specific areas where the risk of infection are at highest. The aim of this project was to produce infection probability maps of the urinary schistosomiasis, caused by the parasite S.haematobium, in order to identify high risk zones where targeted interventions could be undertaken in Burkina Fas

2014

Combining language and space: Sentence bisection in unilateral spatial neglect

In line bisection right-brain-damaged patients with left spatial neglect show a rightward deviation, with respect to the line's physical center. In word bisection ortho-phonological features of the stimulus' final (right-sided) part modulate performance of ...

Academic Press Inc Elsevier Science2014

Boundaries and Urban Worlds. The Contested Ethnoscape of Expatriates in Geneva

After having for long time been neglected by social anthropologists, cities are nowadays central in numerous researches, and more particularly in the field of migration and transnational mobility. However, studies of the impact of migrants on cities themselves remain insufficient. Based on ethnographic work within the United Nations office in Geneva, this paper argues that the impact of international civil servants on the city's settings and space lies in an expatriates' "ethnoscape" (Appadurai 1990) transf

2013

Determination of the antisymmetric part of the chemical shift anisotropy tensor via spin relaxation in nuclear magnetic resonance

Geoffrey Bodenhausen

Relaxation processes induced by the antisymmetric part of the chemical shift anisotropy tensor (henceforth called anti-CSA) are usually neglected in NMR relaxation studies. It is shown here that anti-CSA components contribute to longitudinal relaxation rates of the indole N-15 nucleus in tryptophan in solution at different magnetic fields and temperatures. To determine the parameters of several models for rotational diffusion and internal dynamics, we measured the longitudinal relaxation rates R-1=1/T-1 of

American Institute of Physics2010

Organ Transplantation Management

Organ transplantation is a widespread and effective technique to treat important diseases and can often make the difference between life and death of some patients. Given a donor, finding the best recipient for one of his organs means finding, in the shortest time possible, the patient in the waiting list that best represents the compromise between numerous constraints related to donor-recipient physical compatibility and logistical arrangements. Currently, this process is still done in a non-automated, non

2005

The preparation of organolithium reagents and intermediates

Manfred Schlosser

A review. Only the most important methods for the generation of organometallic reagents and intermediates are covered in this review. This holds for the reductive insertion of Li into org. halides, the permutational interconversion of org. halides with organolithiums, and the permutational interconversion of hydrocarbons with organolithiums. In addn., 3 special methods are featured, the Brook isomerization, the Shapiro reaction and the sulfoxide-alkyllithium interconversion. These topics have been neglected

Wiley2004

Approximate Input-Output Linearization of Nonlinear Systems Using the Observability Normal Form

Dominique Bonvin, Balasubrahmanya Srinivasan

The problem of controlling nonlinear nonminimum-phase systems is considered, where standard input-output feedback linearization leads to unstable internal dynamics. This problem is handled here by using the observability normal form in conjunction with input-output linearization. The system is feedback linearized upon neglecting a part of the system dynamics, with the neglected part being considered as a perturbation. A linear controller is designed to accommodate the perturbation resulting from the approxi

2003

Monosaccharide and disaccharide mimics: New molecular tools for biology and medicine

Pierre Vogel

Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages catalyzed by glycosidases. Monosaccharide and disaccharide mimics such as carbasugars, iminosugars and C-linked disaccharides can be glycosidase or glycosyltransferase inhibitors. They are leads as new drugs to treat infective diseases and cancer. The preparation of a con

2001

Experimental studies of small clusters

Hans Georg Limberger

How do the properties of a solid gradually evolve as atoms are brought together to form increasingly larger units? In order to answer this question one must study aggregates of atoms too large to be called molecules but still too small to have even the structure of a crystal. Recent advances in experimental methods have made possible some first explorations in this long neglected but fascinating field of study.

1987

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