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Concept

Binding site

Related lectures (32)

Protein Folding: Forces and Mechanisms

Explores protein folding forces, including van der Waals interactions, hydrogen bonds, and salt bridges, and their impact on stability.

Self-attraction of DNA: Mediated Interactions

Discusses the self-attraction of DNA and its mediated interactions.

Protein-Ligand Interactions: Importance and Affinity

Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.

Protein-Ligand Interactions

Explores protein-ligand interactions, covering binding affinity, energetics, and various experimental techniques used to study them.

Event Mobility Planning MOOC: Mobility planning

Explores leisure mobilities related to events, modal shares, and traffic management proposals.

Pharmacodynamics: Acid-sensing ion channels and Drug Targets

Explores acid-sensing ion channels, drug targets, and ligand-receptor binding.

Design Optimization in ChemBio

Explores the design optimization of sensors and bioluminescent proteins for drug monitoring and metabolite visualization.

Protein Folding: Free Energy and Interactions

Explores protein folding, free energy, interactions, equilibrium, and binding in cellular processes.

Energy Minimization in Biological Systems: Equilibrium Models

Covers energy minimization models in biological systems, focusing on equilibrium and the roles of entropy and hydrophobicity.

Molecular Mechanism of Hsp70 Chaperones: Interactions with Cochaperones and Substrates

Explores the molecular mechanism of Hsp70 chaperones, focusing on interactions with cochaperones and substrates.

Microsecond Time-Resolved Cryo-EM: Bonus

Explores high-speed protein observations, time-resolved methods, cryo-EM, melting dynamics, and future outlooks.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Pharmacodynamics: Ligand Concentration, Binding, and Effect

Explores the relationship between ligand concentration, binding, and effect, focusing on allosteric modulators and types of pharmacological antagonists.

Kinetics: Reaction Rates and Equilibrium

Explores reaction kinetics, rate laws, measurement techniques, and binding kinetics between ligands and proteins.

Single Proteins Maps: Sabrina Simoncelli

Explores the transition from single-molecule localizations to single proteins maps using DNA-PAINT and k-means clustering.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Inhibitor Design & Analysis Log in to Mediaspace to watch this video

Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.

Untitled Log in to Mediaspace to watch this video

Molecular Binding Assays: Aptamers and Binders Selection Log in to Mediaspace to watch this video

Covers selecting aptamers and binders based on binding affinities and additional properties for downstream testing.

Receptor-Ligand Interaction Log in to Mediaspace to watch this video

Explores receptor-ligand interactions, covering binding, dissociation, equilibrium, and quantification methods.