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Concept

History of cholera

Related publications (24)

Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae's environmental lifestyle

Simon Bernhard Otto

Cholera, caused by the bacterium Vibrio cholerae, has affected humanity throughout history and still impacts millions of people every year. Apart from being a human pathogen, V. cholerae is a common member of the aquatic environment. Due to this natural re ...

EPFL2024

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Alexandre Lemopoulos

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

2024

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Nicolas René Chiaruttini, Loriane Bader, Sandrine Natacha Isaac, Lisa Christina Metzger, Alexis Joseph Proutière

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

2023

Epidemicity of cholera spread and the fate of infection control measures

Andrea Rinaldo, Lorenzo Mari, Damiano Pasetto, Joseph Chadi Benoit Lemaitre, Cristiano Trevisin

The fate of ongoing infectious disease outbreaks is predicted through reproduction numbers, defining the long-term establishment of the infection, and epidemicity indices, tackling the reactivity of the infectious pool to new contagions. Prognostic metrics ...

2022

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Milena Jadwiga Jaskolska, Loriane Bader, Alexis Joseph Proutière

Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...

2022

Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae

Melanie Blokesch, David William Adams, Milena Jadwiga Jaskolska

Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of mobile genetic elements—in particular bacteriophages and plasmids—the ability to share genes within and across species underpins the exceptional adaptability o ...

2022

How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior

Leonardo Filipe Lemos Rocha

The bacterium Vibrio cholerae is the causative agent of the diarrheal disease cholera, which affects millions of people every year. Apart from being a human pathogen, V. cholerae is also a common member of aquatic habitats. Whilst the mechanism that allow ...

EPFL2022

Modeling infectious disease dynamics towards informed public health interventions, with applications on COVID-19 and cholera

Joseph Chadi Benoit Lemaitre

Emerging and existing infectious diseases pose a constant threat to individuals and communities across the world. In many cases, the burden of these diseases is preventable through public health interventions. However, taking the right decisions and design ...

EPFL2021

The molecular treasure box of environmental Vibrio cholerae strains

Natalia Carolina Drebes Dorr

Cholera pandemics have been affecting humankind for centuries and are still considered a major public health problem, especially in regions around the world with poor access to clean water and sanitation. Cholera pandemics are caused by a specific lineage ...

EPFL2021

Rainfall as a driver of epidemic cholera: Comparative model assessments of the effect of intra-seasonal precipitation events

Andrea Rinaldo, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre, Damiano Pasetto

The correlation between cholera epidemics and climatic drivers, in particular seasonal tropical rainfall, has been studied in a variety of contexts owing to its documented relevance. Several mechanistic models of cholera transmission have included rainfall ...

2019

The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study

Andrea Rinaldo, Enrico Bertuzzo, Flavio Finger

Background Cholera prevention and control interventions targeted to neighbors of cholera cases (case-area targeted interventions [CATIs]), including improved water, sanitation, and hygiene, oral cholera vaccine (OCV), and prophylactic antibiotics, may be a ...

2018

Long-Read-Based Genome Sequences of Pandemic and Environmental Vibrio cholerae Strains

Melanie Blokesch, Natalia Carolina Drebes Dorr, Noémie Matthey

The bacterium Vibrio cholerae exhibits two distinct lifestyles, one as an aquatic bacterium and the other as the etiological agent of the pandemic human disease cholera. Here, we report closed genome sequences of two seventh pandemic V. cholerae O1 El Tor ...

2018

Modeling Key Drivers of Cholera Transmission Dynamics Provides New Perspectives for Parasitology

Andrea Rinaldo, Enrico Bertuzzo, Melanie Blokesch, Lorenzo Mari

Hydroclimatological and anthropogenic factors are key drivers of waterborne disease transmission. Information on human settlements and host mobility on waterways along which pathogens and hosts disperse, and relevant hydroclimatological processes, can be a ...

2017

Spatially explicit modeling of cholera epidemics

Flavio Finger

Understanding the epidemiology of cholera, when and where it occurs and how it spreads, is key to its prevention and control. Models can help to apprehend cholera outbreaks by providing insight into critical epidemiological processes, and may be used to ev ...

EPFL2017

On the probability of extinction of the Haiti cholera epidemic

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Flavio Finger

More than three years after its appearance in Haiti, cholera has already caused more than 8,500 deaths and 695,000 infections and it is feared to become endemic. However, no clear evidence of a stable environmental reservoir of pathogenic Vibrio cholerae, ...

Springer Verlag2016

Mobile phone data highlights the role of mass gatherings in the spreading of cholera outbreaks

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Flavio Finger

The spatiotemporal evolution of human mobility and the related fluctuations of population density are known to be key drivers of the dynamics of infectious disease outbreaks. These factors are particularly relevant in the case of mass gatherings, which may ...

National Academy of Sciences2016

Seasonality in cholera dynamics: A rainfall-driven model explains the wide range of patterns in endemic areas

Enrico Bertuzzo, Theo Baracchini

Seasonal patterns in cholera dynamics exhibit pronounced variability across geographical regions, showing single or multiple peaks at different times of the year. Although multiple hypotheses related to local climate variables have been proposed, an unders ...

2017

Real-time projections of cholera outbreaks through data assimilation and rainfall forecasting

Andrea Rinaldo, Enrico Bertuzzo, Flavio Finger, Damiano Pasetto

Although treatment for cholera is well-known and cheap, outbreaks in epidemic regions still exact high death tolls mostly due to the unpreparedness of health care infrastructures to face unforeseen emergencies. In this context, mathematical models for the ...

Elsevier2016

Climate-driven endemic cholera is modulated by human mobility in a megacity

Andrea Rinaldo, Francisco Javier Perez Saez

Although a differential sensitivity of cholera dynamics to climate variability has been reported in the spatially heterogeneous megacity of Dhaka, Bangladesh, the specific patterns of spread of the resulting risk within the city remain unclear. We build on ...

Elsevier2016

Detection of Vibrio cholerae O1 and O139 in environmental waters of rural Bangladesh: a flow-cytometry-based field trial

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Lorenzo Righetto

Presence of Vibrio cholerae serogroups O1 and O139 in the waters of the rural area of Matlab, Bangladesh, was investigated with quantitative measurements performed with a portable flow cytometer. The relevance of this work relates to the testing of a field ...

Cambridge University Press2015