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Concept

Amphetamine

Related publications (29)

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Enrico Amico

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...

Academic Press Inc Elsevier Science2023

Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD

Farnaz Delavari

Objective: To examine whether putatively atypical neuronal activity during internal attention in ADHD yields insights into processes underlying emotion dysregulation. Methods: We used a word processing paradigm to assess neural activations in adults with A ...

2023

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

Maria del Carmen Sandi Perez, Bernard Schneider, Olivia Zanoletti, Simone Astori, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Eva Ramos Fernandez, Elias Georges Gebara, Alessandro Chioino, Sriparna Ghosal

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...

2023

Dopamine Transporter, PhosphoSerine129 alpha-Synuclein and alpha-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice

Salvatore Novello

The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson's disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 alpha-synuclein (pSer129 alpha-syn ...

MDPI2022

Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions

Alessandro Zorzi, Alessandro Angelini

Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting t ...

ELSEVIER2022

Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity

Bernard Schneider

Methamphetamine (METH) is a highly abused psychostimulant that is neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases the risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated ...

MDPI2022

Probing the Limits of Optical Loss in Ion-Sliced Thin-film Lithium Niobate

Tobias Kippenberg, Junqiu Liu, Guanhao Huang, Mikhail Churaev, Zelin Tan

We measured the absorption-limited loss at telecommunication wavelengths for thin-film lithium niobate micro-ring resonators using Kerr-calibrated linear response technique. We find the average absorption loss-rate kappa(abs)/2 pi to be 3.65 +/- 0.70 MHz, ...

IEEE2021

Radical-free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV-induced nonpersistent radicals

Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Andrea Capozzi, Alice Radaelli, Claudia Christina Zanella

It was recently demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with UV light, enabling radical-free dissolution dynamic nuclear polarization. Although pyruvate is endogenous, the ...

WILEY2021

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...

Cell Press2021

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Olivier Burri, Evelyne Ruchti, Brian Donal McCabe, Wei Jiao, Soumya Banerjee, Samuel William Vernon

The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...

Nature Research2021

Sensorimotor Induction of Auditory Misattribution in Early Psychosis

Olaf Blanke, Patric Hagmann, Alessandra Griffa, Andrea Serino, Giulio Rognini, Roy Salomon, Fosco Bernasconi, Silvia Marchesotti

Dysfunction of sensorimotor predictive processing is thought to underlie abnormalities in self-monitoring producing passivity symptoms in psychosis. Experimentally induced sensorimotor conflict can produce a failure in bodily self-monitoring (presence hall ...

2020

The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal-amygdala neural circuitry during positive-social emotion regulation

Dimitri Nestor Alice Van De Ville, Frank Scharnowski, Yury Koush, Gwladys Rey

Positive-social emotions mediate one's cognitive performance, mood, well-being, and social bonds, and represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive emotions in social situations is associated ...

Wiley2020

Revisiting the Urech Synthesis of Hydantoins: Direct Access to Enantiopure 1,5-Substituted Hydantoins Using Cyanobenziodoxolone

Jérôme Waser, Franck Le Vaillant, Nina Declas

A method for the synthesis of enantiopure 1,5-substituted hydantoins was developed using a hypervalent iodine cyanation reagent (cyanobenziodoxolone, CBX) as a source of electrophilic carbon. Starting from inexpensive commercially available enantiopure pro ...

2019

Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

Johannes Gräff, Jose Vicente Sanchez Mut

Background: Metabolic side effects induced by psychotropic drugs represent a major health issue in psychiatry. CREB-regulated transcription coactivator 1 (CRTC1) gene plays a major role in the regulation of energy homeostasis and epigenetic mechanisms may ...

2019

Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity

Bénédicte Marie Maréchal

Background and Purpose- Poststroke fatigue affects a large proportion of stroke survivors and is associated with a poor quality of life. In a recent trial, modafinil was shown to be an effective agent in reducing poststroke fatigue; however, not all patien ...

LIPPINCOTT WILLIAMS & WILKINS2019

HealthSit: Designing Posture-Based Interaction to Promote Exercise during Fitness Breaks

Pearl Pu Faltings, Yu Chen

This research was motivated by a desire to help office workers change their sedentary behavior because a prolonged sedentary posture increases the risks of developing musculoskeletal injuries and chronic diseases, thus threatening their physical and psycho ...

TAYLOR & FRANCIS INC2019

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress

Rolf Gruetter, Maria del Carmen Sandi Perez, Hongxia Lei, João Pedro de Matos Rodrigues, Antoine Timothée Cherix, Thomas Didier Larrieu

Extensive data highlight the existence of major differences in individuals’ susceptibility to stress [1; 2; 3 ; 4]. While genetic factors [5 ; 6] and exposure to early life stress [7 ; 8] are key components for such neurobehavioral diversity, intriguing ob ...

2017

Silver Nitrate-Catalyzed Isocyanide Insertion/Lactamization Sequence to Imidazolones and Quinazolin-4-ones: Development and Application in Natural Product Synthesis

Jieping Zhu, Qian Wang, Antonin François Roland Clemenceau

Silver nitrate-catalyzed reaction of methyl α,α-disubstituted α-isocyanoacetates with primary amines afforded 3,5,5-trisubstituted imidazolones in good to excellent yields. A silver salt-catalyzed insertion of the isocyano group into the N−H bond of the am ...

American Chemical Society2017

The impact of anxiety and reward-seeking traits on social competition and the role of the mesolimbic dopaminergic system

Laura Lozano Montes

Social hierarchies are established across a range of different taxa in the animal kingdom. Given that hierarchy inequalities are highly present in nowadays society and the health problems that low rank individuals suffer from this, it is surprising that no ...

EPFL2015