Publication

Longitudinal Changes in BOLD Variability and Functional Connectivity from Newborn to School-Age in Very Preterm Children

2025

Abstract

Motivation: BOLD-variability predicts cognitive performance (Protzner et al. 2013, Garret et al. 2011), thus may be relevant for studying high-risk populations like preterm infants. Goal(s): This study assesses how RS-fMRI regional BOLD-variability changes from newborn to school-age both longitudinally and cross-sectionally in preterm children compared with full-term controls. Approach: MRI was acquired in 55 very preterm and 27 full-term infants at term-equivalent age, and 14 very preterm and 20 full-term school-age children, of which 11 very preterm and 9 full-term children had longitudinal MRI. Results: Significant increases in BOLD-variability were observed in attention and default mode networks in preterm children, linked to cognitive performance. Impact: Compared to full-term (FT) infants, BOLD-variability is decreased in very preterm (VPT) infants at term-equivalent-age (TEA). It increases from TEA until school-age in VPT children, but not in FT peers. Overall BOLD-variability at school age links to cognitive performance.

Official source

https://infoscience.epfl.ch/entities/publication/52455427-2034-4218-8f9b-1c8e94552b4a

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2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/52455427-2034-4218-8f9b-1c8e94552b4a

About this result

Related concepts (32)

Preterm birth

Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. These babies are also known as premature babies or colloquially preemies (American English) or premmies (Australian English).

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but can also occur through assisted reproductive technology procedures. A pregnancy may end in a live birth, a miscarriage, an induced abortion, or a stillbirth. Childbirth typically occurs around 40 weeks from the start of the last menstrual period (LMP), a span known as the gestational age.

Low birth weight

Low birth weight (LBW) is defined by the World Health Organization as a birth weight of an infant of or less, regardless of gestational age. Infants born with LBW have added health risks which require close management, often in a neonatal intensive care unit (NICU). They are also at increased risk for long-term health conditions which require follow-up over time.

Related publications (2)

Longitudinal Changes in BOLD Variability and Functional Connectivity from Newborn to School-Age in Very Preterm Children

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