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Concept

Genetically modified animal

Related publications (31)

Climbing into their Skin to Understand Contextual Protein-Protein Associations and Localizations: Functional Investigations in Transgenic Live Model Organisms

Yimon Aye

Borrowing some quotes from Harper Lee's novel "To Kill A Mockingbird" to help frame our manuscript, we discuss methods to profile local proteomes. We initially focus on chemical biology regimens that function in live organisms and use reactive biotin speci ...

Wiley-V C H Verlag Gmbh2024

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Freddy Radtke, Etienne Meylan, Nadine Fournier, Amber Dawn Bowler, Justine Pascual, Anita Bodac

Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...

Springernature2024

Gyrokinetic moment-based simulations of the Dimits shift

Paolo Ricci, Baptiste Jimmy Frei, Antoine Cyril David Hoffmann

We present a convergence study of the gyromoment (GM) approach, which is based on projecting the gyrokinetic distribution function onto a Hermite–Laguerre polynomial basis, focused on the cyclone base case (CBC) (Lin et al., Phys. Rev. Lett., vol. 83, no. ...

Cambridge University Press2023

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Sandor Kasas, María Inés Villalba

Cells of two molecular genetic types of breast cancer-hormone-dependent breast cancer (ZR-75 cell line) and triple-negative breast cancer (BT-20 cell line)-were studied using atomic force microscopy and an optical nanomotion detection method. Using the Pea ...

MDPI2023

Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling

Chloé Rogg

Native reactive electrophile species (RES) such as 4-hydroxynonenal (HNE) act as cellular signals through covalent modification of kinetically-privileged electrophile sensor proteins. Research efforts in the field focus mainly on identifying these sensor p ...

EPFL2023

Indentation and stability of woven domes

Pedro Miguel Nunes Pereira de Almeida Reis, Tian Chen, Samuel Jean Bernard Poincloux, Tomohiko Sano, Célestin Vallat

Discrete domes are doubly curved structures comprising a network of beam-like elements. We study the mechanics of discrete domes made of ribbons woven in a pentagonal triaxial pattern. Experiments and finite element simulations are performed to characteriz ...

ELSEVIER2023

Large Orbital Moment of Two Coupled Spin-Half Co Ions in a Complex on Gold

Stefano Rusponi, Chao Li, Boris Sorokin

The magnetic propertiesof transition-metal ions aregenerallydescribed by the atomic spins of the ions and their exchange coupling.The orbital moment, usually largely quenched due the ligand field,is then seen as a perturbation. In such a scheme, S = 1/2 io ...

AMER CHEMICAL SOC2023

The role of Zn in C-S-H atomic structure, nucleation and growth

Anna Morales Melgares

The most promising solution towards cementitious materials with a lower carbon footprint is the partial substitution of the clinker by supplementary cementitious materials (SCMs) such as fly ash, blast furnace slag, limestone and calcined clays. The produc ...

EPFL2023

Interventionist estimands in event history analysis

Matias Janvin

The presence of competing events, such as death, makes it challenging to define causal effects on recurrent outcomes. In this thesis, I formalize causal inference for recurrent events, with and without competing events. I define several causal estimands an ...

EPFL2023

Radiation Performance of Antennas Implanted in Small Animals for Neuroengineering

Anja Skrivervik, Stéphanie Lacour, Mingxiang Gao, Kangling Wu, James Daniel Rosenthal

Wireless data communication could improve the performance and reliability of biomedical implants used in fundamental neuroscience research by removing infection-prone transcutaneous cabling. The small size of common research animals like mice and rodents, ...

IEEE2023

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Marius Alexandru Botos Rogozsan

Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying signa ...

Nature Portfolio2023

Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects

Yong Zhu

Viruses initiate invasion by binding to cell surface glycoproteins. Materials mimicking the carbohydrate motifs of these glycoproteins, such as heparan sulfate (HS) and sialic acid (SA) can block viral attachment and inhibit the infection. Multivalent disp ...

EPFL2023

DNA modifications impact natural transformation of Acinetobacter baumannii

Melanie Blokesch, Nicolas Jean Philippe Guex, Christian Iseli, Alexandre Lemopoulos, Nina Vesel

Acinetobacter baumannii is a dangerous nosocomial pathogen, especially due to its ability to rapidly acquire new genetic traits, including antibiotic resistance genes (ARG). In A. baumannii, natural competence for transformation, one of the primary modes o ...

2023

Engineering Agrobacterium tumefaciens Adhesion to Target Cells

Alexandre Louis André Persat, Xavier Jean-Yves Pierrat, Zaïnebe Dhirani, Jeremy Pak Hei Wong, Alix Kim Lan Pham

Agrobacterium tumefaciens is a plant pathogen commonly repurposed for genetic modification of crops. Despite its versatility, it remains inefficient at transferring DNA to many hosts, including to animal cells. Like many pathogens, physical contact between ...

AMER CHEMICAL SOC2022

Generation of a Gal4-dependent gene recombination and illuminating mouse

Freddy Radtke

Cell labeling technologies, including the Cre/loxP system, are powerful tools in developmental biology. Although the conventional Cre/loxP system has been extensively used to label the expression of specific genes, it is less frequently used for labeling p ...

INT PRESS EDITING CENTRE INC2022

An optimized high throughput platform, from genetic transformation to fermentation, to screen for secreted laccases in Aspergillus niger

Laure Marie Colette Leynaud-Kieffer Curran

Many challenges are faced in the conversion of biomass into advanced biofuels, one of which is finding the correct organism for the job. The filamentous fungus Aspergillus niger has been chosen as a biocatalyst for cellulose, hemicellulose, and lignin degr ...

EPFL2021

Weakly nonlinear evolution of stochastically driven non-normal systems

François Gallaire, Edouard Boujo, Yves-Marie François Ducimetière

We consider nonlinear dynamical systems driven by stochastic forcing. It has been largely evidenced in the literature that the linear response of non-normal systems (e.g. fluid flows) may exhibit a large variance amplification, even in a linearly stable re ...

Cambridge University Press2022

Downscaling of Historical Wind Fields over Switzerland Using Generative Adversarial Networks

Anthony Christopher Davison, Ophélia Mireille Anna Miralles

Near-surface wind is difficult to estimate using global numerical weather and climate models, because airflow is strongly modified by underlying topography, especially that of a country such as Switzerland. In this article, we use a statistical approach ba ...

2022

Dissecting the role of the asparagine synthesis in acute liver injury

Yu Sun

Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...

EPFL2022

Optimal Co-Planning of ESSs and Line Reinforcement Considering the Dispatchability of Active Distribution Networks

Mario Paolone, Sidi-Rachid Cherkaoui, Ji Hyun Yi

The paper presents a method for the co-optimization of energy storage systems allocation and line reinforcement in active distribution networks. The objective is to guarantee the capability of an active distribution network to follow a dispatch plan by app ...

IEEE Institute of Electrical and Electronics Engineers2022