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Concept

Insulin (medication)

Related publications (31)

Gamma Knife radiosurgery for acromegaly: Evaluating the role of the biological effective dose associated with endocrine remission in a series of 42 consecutive cases

Constantin Tuleasca

Introduction Stereotactic radiosurgery (SRS) is a valuable treatment option for persistent and/or recurrent acromegaly secondary to growth hormone (GH) secreting pituitary adenoma (PA). Here, we assess the role of biological effective dose (BED) received b ...

2021

Amoebocytes facilitate efficient carbon and nitrogen assimilation in the Cassiopea -Symbiodiniaceae symbiosis

Anders Meibom, Stéphane Laurent Escrig, Nils Rädecker, Louise Helene Soegaard Jensen, Niclas Heidelberg Lyndby, Sandrine Denise Françoise Bessette

The upside-down jellyfish Cassiopea engages in symbiosis with photosynthetic microalgae that facilitate uptake and recycling of inorganic nutrients. By con- trast to most other symbiotic cnidarians, algal endosymbionts in Cassiopea are not restricted to th ...

2020

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

A high sensitivity low-power capacitive front-end for insulin injection pens

Maher Kayal, François Krummenacher, Jean-Baptiste Robert Orhan, François Pierre Gaugaz

A low-power 14-bits first order incremental Analog-to-Digital Converter (ADC) is presented. Based on the charge balancing principle, this switched-capacitor (SC) circuit integrates the input signal multiple times to reach the targeted resolution, linearity ...

ELSEVIER SCI LTD2019

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Catherine Dehollain, Maria-Alexandra Paun, Jean-Baptiste Robert Orhan

A fully parameterized three-dimensional model with specific dimensions has been developed in ANSYS for an insulin injection pen used by diabetic persons. The insulin injection pen has a smart pen cap which hosts four electrodes used for the smart pen cap e ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

2019

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Rolf Gruetter, Hongxia Lei

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

2019

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Isabelle Chareyron

Glucose sensing and regulation of insulin secretion are the two main functions performed by the pancreatic beta-cell. Together these processes contribute to the tight control of blood glucose in our body. Compromising the ability of the beta-cells to prope ...

EPFL2019

High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model

Silvestro Micera

Overactivity of the sympathetic nervous system (SNS) is associated to several cardiovascular and metabolic dysfunctions, such as hypertension and insulin resistance. Indirect biochemical measurements and surgical manipulations have provided preliminary evi ...

IEEE2019

A bioactive injectable bulking material; a potential therapeutic approach for stress urinary incontinence

Jeffrey Alan Hubbell, Matthias Lütolf, Peter Frey, Hans Mattias Larsson, Elif Vardar

Stress urinary incontinence (SUI) is a life changing condition, affecting 20 million women worldwide. In this study, we developed a bioactive, injectable bulking agent that consists of Permacol (TM) (Medtronic, Switzerland) and recombinant insulin like gro ...

ELSEVIER SCI LTD2019

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Chiara Cianciaruso, Steinunn Baekkeskov Hanahan, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019