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Concept

Chronic pancreatitis

Related publications (12)

Quantitative T2 Mapping of Acute Pancreatitis

Tom Hilbert

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...

Wiley2024

New ingredients for old recipes

Didier Trono, Filipe Amândio Brandão Sanches Vong Martins, Olga Marie Louise Rosspopoff

The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory network controlled by the KRAB z ...

2023

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

Loïc Dayon, Andreas Wiederkehr, Isabelle Chareyron

Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...

2020

Patient respiratory-triggered quantitative T-2 mapping in the pancreas

Tobias Kober, Reto Meuli, Josefina Adriana Maria Bastiaansen, Tom Hilbert

Background Long acquisition times and motion sensitivity limit T-2 mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free-breathing. Purpose To test the feasibility of ...

2019

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Sandrine Gerber, Daniel Ortiz Trujillo, François Rémi Pierre Noverraz, Luca Szabó

The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...

2018

Vitamin E and Vitamin E Acetate Absorption from Self-assembly Systems under Pancreas Insufficiency Conditions

We determined the bioavailability of vitamin E from self-assembly structures in patients with diagnosed chronic pancreas insufficiency. Vitamin E solubilized in dispersed inverted bicontinuous cubic phase and in micellar formulation was delivered directly ...

Swiss Chemical Soc2014

Artificial three-dimensional niches deconstruct pancreas development in vitro

Matthias Lütolf, Anne Grapin-Botton, Adrian Ranga, Samy Gobaa, Chiara Greggio, Filippo De Franceschi

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells would be extremely valuable. Here we establish three-dimensional culture conditions in Matrigel ...

Company Of Biologists Ltd2013

Neurogenin3 Initiates Stepwise Delamination of Differentiating Endocrine Cells During Pancreas Development

Anne Grapin-Botton, Yung Hae Kim, Keiichi Katsumoto

During development, pancreatic endocrine cells are specified within the pancreatic epithelium. They subsequently delaminate out of the epithelium and cluster in the mesenchyme to form the islets of Langerhans. Neurogenin3 (Ngn3) is a transcription factor r ...

2011

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Philipp Bucher

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Conditional ablation of Notch signaling in pancreatic development

Freddy Radtke

The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore analyzed conditional pancreas-specific Rbpj and combined Notch1/Notch2 knockout mice using Ptf1a(+/Cre(ex1)) mice crossed w ...

2008

Pancreas development and cancer - Wnt/beta-catenin at issue

Anne Grapin-Botton

beta-catenin and Adenomatous poliposis coli (APC) have been implicated in non-ductal pancreatic cancers. As for many other organs, several recent publications show that beta-catenin and more largely the Wnt pathway appear to function at the level of pancre ...

2006

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

Jörg Hülsken, Anne Grapin-Botton

Mutations and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown [1-4]. This article reports a comprehe ...

2005