Explores the design and validation of targeted protein degraders, including PROTACs and molecular glue compounds, emphasizing the importance of proper analyses and validations in TPD research.
Covers the basics of tissue engineering, laboratory introductions, recommended courses, autografting, allografting, FDA-approved tissue products, and current research challenges.
Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.
Explores molecular machines in mycobacterial protein quality control pathways, focusing on degradation, proteases, and pupylation-dependent degradation.
Explores organoids, miniature tissue constructs mimicking living tissues, covering derivation methods, applications, and bridging in vitro and in vivo models.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
