Lecture

Organoids: Miniature Multicellular Tissue Constructs

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Description

This lecture explores the concept of organoids, which are miniature in vitro constructs mimicking the architecture, cell composition, and function of living tissues. It covers the derivation methods, applications in basic biology, disease modeling, drug discovery, and regenerative medicine. The lecture delves into the origins of organoids, different cell/tissue culture approaches, stem cell-based morphogenesis, and the main features of organoids. It also discusses the bridging role of organoids between in vitro and in vivo models, comparing them with traditional in vitro systems. Furthermore, it highlights the use of organoids in modeling genetic diseases, host-pathogen interactions, and cancer, showcasing their potential in disease modeling, drug discovery, and personalized medicine.

Official source

Ontological neighbourhood

Biological engineering

Biomedical engineering: Tissue engineering

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Cancer stem cell

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Stem cell

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Adult stem cell

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. Scientific interest in adult stem cells is centered around two main characteristics.

Embryonic stem cell

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