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Adaptive optics enables multimode 3D super-resolution microscopy via remote focusing

Publications associées (31)

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As the data volume grows, reducing the query execution times remains an elusive goal. While approximate query processing (AQP) techniques present a principled method to trade off accuracy for faster queries in analytics, the sample creation is often consid ...

ACM2022

ON WAVEFRONT ABERRATIONS IN ASYMMETRIC AND MULTIPLE APERTURE OPTICAL SYSTEMS

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The present work deals with monochromatic wavefront aberrations in optical systems without symmetries. The treatment begins with a class of systems characterized by misaligned spherical surfaces whose behavior is analyzed using the wavefront aberration exp ...

EPFL2021

Optical diffraction tomography from single-molecule localization microscopy

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Single-molecule localization microscopy (SMLM) is a powerful method for the imaging of cellular structures. This modality delivers nanoscale resolution by sequentially activating a subset of fluorescent molecules and by extracting their super-resolved posi ...

2021

Structured light generation by refractive-diffractive micro optical array illuminators

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Structured light generation having broad applications in different optical fields, is the topic of this thesis. Our structured light generation strategy is based on applying periodic microoptical elements at the refraction-diffraction limit, under a focuse ...

EPFL2021

Biophysical applications of correlative scanning probe and super-resolution microscopy

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Imaging live cells in their native environment is crucial for the understanding of complex biological phenomena. Modern optical microscopy methods such as fluorescence super-resolution microscopy are increasingly combined with complementary, label-free tec ...

EPFL2021

True scale-free networks hidden by finite size effects

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We analyze about 200 naturally occurring networks with distinct dynamical origins to formally test whether the commonly assumed hypothesis of an underlying scale-free structure is generally viable. This has recently been questioned on the basis of statisti ...

National Academy of Sciences2021

Systematic Tuning of Rhodamine Spirocyclization for Super-resolution Microscopy

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Rhodamines are the most important class of fluorophores for applications in live-cell fluorescence microscopy. This is mainly because rhodamines exist in a dynamic equilibrium between a fluorescent zwitterion and a nonfluorescent but cell-permeable spirocy ...

AMER CHEMICAL SOC2021

Weakly Supervised Deep Learning Methods for Biomicroscopy

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Optical microscopy, an invaluable tool in biology and medicine to observe and quantify cellular function, organ development, or disease mechanisms, requires constant trade-offs between spatial, temporal, and spectral resolution, invasiveness, acquisition t ...

EPFL2021

Uncertain Sampling with Certain Priors

Golnooshsadat Elhami

Sampling has always been at the heart of signal processing providing a bridge between the analogue world and discrete representations of it, as our ability to process data in continuous space is quite limited. Furthermore, sampling plays a key part in unde ...

EPFL2021

Locally Differentially-Private Randomized Response for Discrete Distribution Learning

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We consider a setup in which confidential i.i.d. samples X1, . . . , Xn from an unknown finite-support distribution p are passed through n copies of a discrete privatization chan- nel (a.k.a. mechanism) producing outputs Y1, . . . , Yn. The channel law gua ...

2021

Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy

Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Georg Fantner, Samuel Mendes Leitão, Kristin Stefanie Grussmayer, Barney Frederick Drake, Vytautas Navikas

High-resolution live-cell imaging is necessary to study complex biological phenomena. Modern fluorescence microscopy methods are increasingly combined with complementary, label-free techniques to put the fluorescence information into the cellular context. ...

Nature Research2021