Publications associées à Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Publications associées (11)

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

BMC2025

Computational Generation of Long-range Axonal Morphologies

Rémy Valentin Petkantchin, Adrien Berchet, Henry Markram, Lida Kanari

Long-range axons are fundamental to brain connectivity and functional organization, enabling communication between different brain regions. Recent advances in experimental techniques have yielded a substantial number of whole-brain axonal reconstructions. ...

HUMANA PRESS INC2025

Development of Small Molecule Heparin Glycomimetics for Applications in Nerve Regeneration Therapies

Melis Özkan

Heparin and heparan sulfate (HS) glycosaminoglycans (GAGs), essential components of the extracellular matrix (ECM), regulate a vast array of biological processes by modulating protein interactions and cellular signaling. Their structural complexity, driven ...

EPFL2025

Targeting the brain after spinal cord injury: Targeted deep brain stimulation improves walking after injury

Newton Cho

Targeted deep brain stimulation improves walking after injury. ...

American Association for the Advancement of Science2025

A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

Jinyun Wu, Ralf Schneggenburger, Olexiy Kochubey, Denys Osypenko, Shriya Palchaudhuri, Bei-Xuan Lin

During fear learning, associations between a sensory cue (conditioned stimulus, CS) and an aversive stimulus (unconditioned stimulus, US) are formed in specific brain circuits. The lateral amygdala (LA) is involved in CS-US integration; however, US pathway ...

2025

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Yesica Gloria

Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stage ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

NeuroCHI: Are We Prepared for the Integration of the Brain with Computing?

Olaf Blanke

Recent advancements in neuroscience, wearable technology, and artificial intelligence are paving the way for computing systems that are integrated with the brain and nervous system. Over the past years, we have witnessed the simultaneous progression of wea ...

ACM2024

Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement

Friedhelm Christoph Hummel, Traian Popa, Sylvain Jean-François Harquel, Pablo Maceira Elvira, Umberto Nencha

Aging populations face significant cognitive challenges, particularly in working memory (WM). Transcranial alternating current stimulation (tACS) offer promising avenues for cognitive enhancement, especially when inspired by brain physiology. This study (N ...

2024

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Stéphanie Lacour, Florian Dylan Fallegger, Alix Esther Anne Trouillet

Neurological impairments and diseases can be diagnosed or treated using electrocorticography (ECoG) arrays. In drug-resistant epilepsy, these help delineate the epileptic region to resect. In long-term applications such as brain-computer interfaces, these ...

JOURNAL OF VISUALIZED EXPERIMENTS2023

Relocation incentives for ride-sourcing drivers with path-oriented revenue forecasting based on a Markov Chain model

Nikolaos Geroliminis, Caio Vitor Beojone

Proper positioning of ride-sourcing drivers may improve vacant travel times, waiting times, and matching opportunities. Herein, we evaluate the potential repositioning response of drivers when provided guidance based on estimates of their earnings in a sys ...

Pergamon-Elsevier Science Ltd2023

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022