Digital Reconstruction of the Neuro-Glia-Vascular Architecture

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BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

Long-range axons are fundamental to brain connectivity and functional organization, enabling communication between different brain regions. Recent advances in experimental techniques have yielded a substantial number of whole-brain axonal reconstructions. ...

Targeted deep brain stimulation improves walking after injury. ...

During fear learning, associations between a sensory cue (conditioned stimulus, CS) and an aversive stimulus (unconditioned stimulus, US) are formed in specific brain circuits. The lateral amygdala (LA) is involved in CS-US integration; however, US pathway ...

Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stage ...

Recent advancements in neuroscience, wearable technology, and artificial intelligence are paving the way for computing systems that are integrated with the brain and nervous system. Over the past years, we have witnessed the simultaneous progression of wea ...

Aging populations face significant cognitive challenges, particularly in working memory (WM). Transcranial alternating current stimulation (tACS) offer promising avenues for cognitive enhancement, especially when inspired by brain physiology. This study (N ...

Neurological impairments and diseases can be diagnosed or treated using electrocorticography (ECoG) arrays. In drug-resistant epilepsy, these help delineate the epileptic region to resect. In long-term applications such as brain-computer interfaces, these ...

Proper positioning of ride-sourcing drivers may improve vacant travel times, waiting times, and matching opportunities. Herein, we evaluate the potential repositioning response of drivers when provided guidance based on estimates of their earnings in a sys ...

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

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CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

Computational Generation of Long-range Axonal Morphologies

Targeting the brain after spinal cord injury: Targeted deep brain stimulation improves walking after injury

A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

NeuroCHI: Are We Prepared for the Integration of the Brain with Computing?

Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Relocation incentives for ride-sourcing drivers with path-oriented revenue forecasting based on a Markov Chain model