Publication

The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers

Publications associées (32)

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

EPFL2024

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Chen Zhang

Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

EPFL2024

Quantified interface chemistry and biophysics via water imaging

Sylvie Roke

High throughput wide-field second harmonic imaging enables the label-free imaging of interfacial (< 3 nm thick) water, with a spatial resolution of similar to 370 nm using similar to 100 ms acquisition times per image. The obtained interfacial orientationa ...

Spie-Int Soc Optical Engineering2024

Process development of pre-impregnated hybrid thin-ply composites

Alexios Argyropoulos

Thin-ply composites, obtained with recently developed fiber spreading techniques, rapidly gained industrial interest because they offer a large composite design freedom, and lead to a composite tensile strength that is close to that of the individual fiber ...

EPFL2023

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

Samuel Mendes Leitão

The evolution of the 3D morphology is at the center of many relevant biological processes ranging from cellular differentiation to cancer invasion and metastasis. Microscopy techniques, such as electron microscopy (EM), super-resolution (SR) optical micros ...

EPFL2023

Space-time wave packets with reduced divergence and tunable group velocity generated in free space after multi-mode fiber propagation

Tobias Kippenberg, Hao Song, Maxim Karpov, Xinzhou Su

Previously, space-time wave packets (STWPs) have been gen-erated in free space with reduced diffraction and a tunable group velocity by combining multiple frequency comb lines each carrying a single Bessel mode with a unique wave num-ber. It might be poten ...

Optica Publishing Group2023

Multi-scale characterization and modeling of notched strength and translaminar fracture in hybrid thin-ply composites based on different carbon fiber grades

Guillaume Clément Broggi

Owing to their high specific stiffness and strength, Carbon Fiber Reinforced Composites (CFRP) are ideal candidates for the development of lightweight high-performance structures. Within this family, thin-ply composites allow for wider design freedom and p ...

EPFL2023

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Sandor Kasas, María Inés Villalba

Cells of two molecular genetic types of breast cancer-hormone-dependent breast cancer (ZR-75 cell line) and triple-negative breast cancer (BT-20 cell line)-were studied using atomic force microscopy and an optical nanomotion detection method. Using the Pea ...

MDPI2023

3D printed fiber-optic nanomechanical bioprobe

Sandor Kasas, Yuguang Chen, Jiangtao Zhou, Yiping Wang

Ultrasensitive nanomechanical instruments, e.g. atomic force microscopy (AFM), can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes. However, these instruments are limited because ...

IOP Publishing Ltd2023

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells

Nora Guidotti, Maxime Nicolas Mivelaz, Beat Fierz, Pablo Rivera Fuentes, Adam Miklos Eördögh

Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated “reader” proteins. Different models for the underlying mecha ...

2022

SBS-based fiber sensors

Luc Thévenaz

The spectra of Brillouin scattering processes in optical fibers are affected by temperature, axial strain, and other quantities of interest. This dependence forms the basis for optical Brillouin scattering based optical fiber sensors. Since the first propo ...

Elsevier2022

Carbon nanotube uptake in cyanobacteria for near-infrared imaging and enhanced bioelectricity generation in living photovoltaics

Vitalijs Zubkovs, Ardemis Anoush Boghossian, Alessandra Antonucci, Charlotte Elisabeth Marie Roullier, Nils Schürgers, Benjamin Paul Johanès Gabriel Lambert, Alice Judith Gillen, Melania Reggente, Mohammed Mouhib

Single-walled carbon nanotubes (SWCNTs) have unique optoelectronic properties that make them suitable for applications ranging from phototherapy to imaging and sensing, but their uptake has mainly been explored in eukaryotic cells. Here the authors explore ...

2022

Fiber Buckling in Confined Viscous Flows: An Absolute Instability Described by the Linear Ginzburg-Landau Equation

François Gallaire, Jean Cappello

We explore the dynamics of a flexible fiber transported by a viscous flow in a Hele-Shaw cell of height comparable to the fiber height. We show that long fibers aligned with the flow experience a buckling instability. Competition between viscous and elasti ...

AMER PHYSICAL SOC2022

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Didier Trono, Laurence Gouzi Abrami, Julien Léonard Duc, Sandra Eloise Kjeldsen, Alexandre Coudray, Sagane Dind, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

Nature Research2022

Enhanced Signal-Associated Noise in a φ-OTDR System

Luc Thévenaz, Malak Mohamed Hossameldeen Omar Mohamed Galal, Suneetha Sebastian

Owing to their high sensitivity with respect to external measurands, Rayleigh-based distributed optical fiber sensors (DOFS) find their way into applications in many industrial and academic sectors. To further transcend the limit of these sensors in terms ...

2022

A Kilometre-range Distributed Relative Humidity Fibre Sensor

Tiago Filipe Pimentel Das Neves

Fibre optics sensors have been identified as very good candidates for environmental monitoring inside the silicon detectors operated at CERN's Large Hadron Collider. The objective of this dissertation is the development of a Relative Humidity (RH) distribu ...

EPFL2022

Temporal Talbot effect of optical dark pulse trains

Camille Sophie Brès, Jianqi Hu, Jiaye Wu

The temporal Talbot effect describes the periodic self-imaging of an optical pulse train along dispersive propagation. This is well studied in the context of bright pulse trains, where identical or multiplied pulse trains with uniform bright waveforms can ...

OPTICAL SOC AMER2022

Analysis and Modeling of the Dynamics of Traction Forces during Cell Polarization and their Role in the Organization of Edge Activity

Zeno Messi

The capacity to break symmetry and organize activity to move directionally is a fundamental property of eukaryotic cells. To explain the organization of cell-edge activity, models commonly rely on front-to-back gradients of functional components or regulat ...

EPFL2021

Visualizing intracellular nanostructures of living cells by nanoendoscopy-AFM

Marcos Penedo Garcia

Atomic force microscopy (AFM) is the only technique that allows label-free imaging of nanoscale biomolecular dynamics, playing a crucial role in solving biological questions that cannot be addressed by other major bioimaging tools (fluorescence or electron ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Microfabricated nanomotion detectors for rapid cells viability tests

Anton Malovichko

The widespread use of antibiotics and antifungal drugs has provoked an increasing number of multi-resistant bacteria and fungi. The emergence of multiresistance to antibiotics has been now recognized as a very serious public health issue. In order to targe ...

EPFL2021