Publications associées à Fine-tuning the cytotoxicity of ruthenium(ii) arene compounds to enhance selectivity against breast cancers

Publications associées (5)

Genomic loci influence patterns of structural covariance in the human brain

Normal and pathologic neurobiological processes influence brain morphology in coordi-nated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases. The genetic underpinnings of the ...

National Academy of Sciences2023

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Bruno Lemaitre, Paolo De Los Rios, Giovanni D'Angelo, Anthony Vocat, Evelyne Ruchti, Stefano Zamuner, Samuel Rommelaere, Charlotte Julie Caroline Gehin, Sylvia Ho, Laura Capolupo, Greta Limoni, Marine Van Campenhoudt, Samuel Sagar Kumar, Huixin Guo

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

American Society for Clinical Investigation2023

Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade

Natalia Gasilova, Laure Menin

Monoclonal antibodies (mAbs) are protein biotherapeutics with a proven efficacy toward fighting life-threatening diseases. Their exceptional healing potential drives the annual increase in the number of novel mAbs and other antibody-like molecules entering ...

SWISS CHEMICAL SOC2022

Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation

Philipp Bucher, Cathrin Brisken, Giovanna Ambrosini, Valentina Scabia, Laura Battista, Fabio De Martino, Céline Berthe Constantin, Marie Shamseddin, Csaba Ferenc László

Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate mode ...

2021

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

Amaia Martinez Usatorre

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced ...

FRONTIERS MEDIA SA2020