Publication

On the O'Brien-Jarrett-Marchi law

Publications associées (30)

From experimental evidence to mechanical modeling and design expressions: The Critical Shear Crack Theory for shear design

Many research efforts have so far been devoted to the topic of shear design of members without transverse reinforcement since the first development in structural concrete. This has allowed a number of significant advances in the understanding of the phenom ...

2019

Navigating the validity tradeoffs of entrepreneurship research experiments: A systematic review and best-practice suggestions

Jérémy Binder, Julia Katharina Binder

Experimental methods provide important advantages for advancing academic understanding of entrepreneurship. Yet, the complex and comingled relationships between some of entrepreneurship's key characteristics pose thorny methodological challenges to entrepr ...

ELSEVIER SCIENCE BV2019

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Pierre Magistretti

Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...

FRONTIERS MEDIA SA2019

Resilience and agency in mature sustainability transitions. Theoretical conceptualisation and empirical analysis of actor- & system-level dynamics in sociotechnical energy systems

Susan Marie Mühlemeier

In Switzerland, Germany and Austria, as in many European countries, the transition of the energy sector towards more sustainability is a long-term transition process, unfolding since decades. It however only reached the regime level in recent years and the ...

EPFL2019

Unexpected large evasion fluxes of carbon dioxide from turbulent streams draining the world’s mountains

Enrico Bertuzzo, Tom Ian Battin, Amber Joy Ulseth, Pier Luigi Segatto, Asa Lovisa Viktoria Horgby

Inland waters, including streams and rivers, are active components of the global carbon cycle.Despite the large areal extent of the world’s mountains, the role of mountain streams forglobal carbonfluxes remains elusive. Using recent insights from gas excha ...

Nature Research2019

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Silvestro Micera, Francesco Saverio Pavone, Stefano Lai

Rehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by rehabilitative ther ...

2019

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor

Carlos Canto Alvarez, Richardus Houtkooper, Sofia Moco

Objective: A decay in intracellular NAD(+) levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD(+) precursors can prevent, alleviate, or even reverse multiple metabolic complicati ...

2019

Governance of Trust in Precision Medicine

Marie-Valentine Renée Agnès Florin, Kujtesë Bejtullahu Michalopoulos

Following up a two-day invitation-only expert workshop in Geneva on the subject of Trust and Precision Medicine, IRGC published a workshop report in April 2018. This report addresses the concept of trust and conditions of trustworthiness in each of the thr ...

EPFL International Risk Governance Center2018

Breaking size-segregation waves and mobility feedback in dense granular avalanches

Christophe Ancey, Kasper van der Vaart

Through experiments and discrete particle method (DPM) simulations we present evidence for the existence of a recirculating structure, that exists near the front of dense granular avalanches, and is known as a breaking size-segregation (BSS) wave. This is ...

2018

Unspanned stochastic volatility in the multifactor CIR model

Damir Filipovic, Martin Larsson, Francesco Statti

Empirical evidence suggests that fixed-income markets exhibit unspanned stochastic volatility (USV), that is, that one cannot fully hedge volatility risk solely using a portfolio of bonds. While Collin-Dufresne and Goldstein (2002, Journal of Finance, 57, ...

2019