Mechanotaxis directs Pseudomonas aeruginosa twitching motility

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Breaking Silos to Guarantee Control Stability with Communication over Ethernet TSN

Amir Aminifar

Editor's notes: The cross-layer approach presented in this article involves co-designing a feedback controller's parameters together with the schedule of an Ethernet network used for communicating state information and control signals.-Samarjit Chakraborty ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

Umji Lee

Skeletal muscle is one of the most dynamic organs in the human body, which has a vigorous potential to regenerate and adapt to environmental changes. Depending on environments, skeletal muscle enables essential life activities to survive by controlling mov ...

EPFL2021

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Davide D'Amico, Pamela Solange Valdés Undurraga, Pénélope Andreux

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Bart Deplancke, Daniel Alpern, Julie Marie Russeil

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated ...

2021

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Johan Auwerx, Tanes Imamura de Lima

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

Nature Portfolio2021

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Changmyung Oh, Johan Auwerx, Hongbo Zhang, Hao Li, Vincenzo Sorrentino, Tanes Imamura de Lima, Mario Romani

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...

2021

Investigation of physiological roles of AMPK-activated protein kinase y3

Philipp Jurijvic Rhein

Clinical trials have shown that direct activators of an evolutionary-conserved metabolic sensor, AMP-activated protein kinase (AMPK), are beneficial in preventing/treating a range of metabolic disorders, including type 2 diabetes. These activators, includi ...

EPFL2021

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Mario Romani

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

EPFL2021

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Johan Auwerx, Hao Li, Davide D'Amico, Pénélope Andreux, Tanes Imamura de Lima, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Peiling Luan

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

AMER ASSOC ADVANCEMENT SCIENCE2021