Mechanotaxis directs Pseudomonas aeruginosa twitching motility

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Skeletal muscle is one of the most dynamic organs in the human body, which has a vigorous potential to regenerate and adapt to environmental changes. Depending on environments, skeletal muscle enables essential life activities to survive by controlling mov ...

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated ...

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...

Clinical trials have shown that direct activators of an evolutionary-conserved metabolic sensor, AMP-activated protein kinase (AMPK), are beneficial in preventing/treating a range of metabolic disorders, including type 2 diabetes. These activators, includi ...

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

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Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Investigation of physiological roles of AMPK-activated protein kinase y3

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy