Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

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Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

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Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...

We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult he-matopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs ...

Nanopores in solid state membranes are a tool able to probe nanofluidic phenomena or can act as a single molecular sensor. They also have diverse applications in filtration, desalination, or osmotic power generation. Many of these applications involve chem ...

Early diagnosis of acute cartilage injuries enables monitoring of disease progression and improved treatment option planning to prevent post-traumatic osteoarthritis. In contrast-enhanced computed tomography (CECT), the changes in cationic agent diffusion ...

Although distributed fiber-optic sensing of axial strain and temperature is a well-established technique, there are almost no demonstrations of distributed hydrostatic pressure sensing. The main obstacle for such measurements is the low sensitivity to pres ...

In this study, the effect of spilling from neighboring sluice gates on stop-logs was experimentally investigated on a 1:65 physical scale model comprised of a double arch dam, a reservoir area, six spillway orifices and two stop-logs. Two types of measurem ...

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

When water flows through hydraulic turbomachines, the local pressure can become low enough to vaporize the water and create vapor cavities. This phenomenon is called cavitation. When the cavities collapse, shock waves and liquid jets traveling through the ...

Engineered artificial microenvironments hold enormous potential as models to study developmental, physiological, pathological, and regenerative processes under highly defined conditions. Such platforms aim at bridging the gap between traditional in vitro 2 ...

High-velocity plunging jets, issuing from ood release structures of dams, may result in scouring of the rocky riverbed and even endanger the foundation of the dams. Assessment of the scour extent is essential to ensure the safety of the dam and appurtenant ...

Cell organization into functional multicellular three-dimensional structures is a long-standing challenge. In particular, engineering of vascularized tissues requires both blood and lymphatic neovascular network formation in a simultaneous and coordinated ...

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4'-methyl-2,2'-bipyri ...

We present a newly-developed microwave probe for performing sensitive high-field/multi-frequency electron spin resonance (ESR) measurements under high hydrostatic pressures. The system consists of a BeCu-made pressure-resistant vessel, which accommodates t ...

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

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Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

Pressure-Induced Enlargement and Ionic Current Rectification in Symmetric Nanopores

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Distributed hydrostatic pressure measurement using phase OTDR in a highly birefringent photonic crystal fiber

Effect of spilling from adjacent orifices on the velocity field and pressures in front of needle stop-logs

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

The effect of pressure gradient on the collapse of cavitation bubbles in normal and reduced gravity

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

Response of an Embedded Block Impacted by High-Velocity Jets

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Continuous-wave far-infrared ESR spectrometer for high-pressure measurements