New methods for developing (bi)cyclic peptides by phage display

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Protein-protein interactions (PPIs) are responsible for regulating many biological processes in human bodies. PPIs often have a large binding site and often interact through an alpha helical segment. Therefore, the inhibition of PPIs can be difficult using ...

At present, there is no general standard automated method for engineering metalloenzymes, industrially-relevant systems able to catalyze environmentally friendly reactions. One of the most studied natural metalloenzymes is the second isoform of human carbo ...

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

Macrocycles have raised much interest in the pharmaceutical industry due to their ability to bind challenging targets while often still being able to cross membranes to reach intracellular proteins. However, the development of macrocyclic ligands to new di ...

The ability to identify peptides with single-molecule sensitivity would lead to next-generation proteomics methods for basic research and clinical applications. Existing single-molecule peptide sequencing methods can read some amino acid sequences, but the ...

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or ba ...

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses. ...

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

New methods for developing (bi)cyclic peptides by phage display

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Synthesis and application of bifunctional hypervalent iodine reagents for peptide modification

Computational Studies for the Design of Metalloenzyme Mimics

De novo designed proteins: a study in engineering novel folds and functions

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints

Inhibitors of acyl protein thioesterases against microbial infections

Systematic benchmarking of single-cell ATAC-sequencing protocols

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease