Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclein (alpha-Syn) protein. Consequently, there is growing interest in understanding how the gut (commensal) microbiome can regulate alpha-Syn accumulation, as this could potentially lead to PD.