Mutations in the TARDBP gene, which encodes the TDP-43 protein, account for only 3–5% of familial cases of amyotrophic lateral sclerosis and less than 1% of cases that are apparently idiopathic. However, the discovery of neuronal inclusions of TDP-43 as th ...
Understanding the brain requires studying its multiscale interactions from molecules to networks. The increasing availability of large-scale datasets detailing brain circuit composition, connectivity, and activity is transforming neuroscience. However, int ...
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson’s disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induc ...
Ruthenium-based complexes have been suggested as promising anticancer drugs exhibiting reduced general toxicity compared to platinum-based drugs. In particular, Ru(& eta;(6)-arene)(PTA)Cl-2 (PTA = 1,3,5-triaza-7-phosphaadamantane), or RAPTA, complexes have ...
Confirmatory Factor Analysis is an advanced statistical method used to test a pre-established hypothesis about the underlying relationships among observed variables using a limited set of factors. The primary step in the complete modeling process involves ...
Institute of Electrical and Electronics Engineers Inc.2023
Autoencoders are the simplest neural network for unsupervised learning, and thus an ideal framework for studying feature learning. While a detailed understanding of the dynamics of linear autoencoders has recently been obtained, the study of non-linear aut ...
Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate mode ...
