Publications associées à Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

Publications associées (9)

Enterovirus A71 priorities, challenges, and future opportunities in humoral immunity and vaccine development

Enterovirus A71 (EV-A71) is a significant public health concern, particularly in the Asia-Pacific region, where it commonly causes hand, foot, and mouth disease outbreaks. There are no clinically available antivirals, and use of inactivated vaccine is rest ...

2025

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Simon Sie-Mon Tang, Jacques Fellay, Zhi Ming Xu, Dylan Lawless, Olivier Noël Marie Naret, Sina Rüeger

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to ...

Springer Science and Business Media LLC2025

Leveraging chromatin modules to explore the impact of regulatory variation on disease

Olga Pushkarev

Human genome is complex and hierarchically organized within the nucleus, where cis-regulatory elements (CREs) frequently interact within topologically associated domains to regulate gene expression. While genomic technologies and computational approaches h ...

EPFL2025

Trajectories of macrophage ontogeny and reprogramming in cancer

Mehdi Louis Hicham, Michele De Palma, Nahal Mansouri, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Florent Philippe Maurice Duval, Céline Wyser Rmili

Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

2025

Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single-Cell Mass Cytometry

Sènan Mickaël Marius Antoine D'Almeida

The increasing exposure to nanoplastics (NPs) raises significant concerns for human health, primarily due to their potential bioaccumulative properties. While NPs have recently been detected in human blood, their interactions with specific immune cell subt ...

2024

The skin microbiome in the first year of life and its association with atopic dermatitis

Alexis Rapin

BackgroundEarly-life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbio ...

WILEY2023

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Jacques Fellay

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in similar to 20% of dec ...

National Academy of Sciences2022

Stay positive: catalysis with 1,3,2-diazaphospholenes

Nicolai Cramer, John Henry Reed, Johannes Klett

P-Hydrido 1,3,2-diazaphospholenes (DAPs) are a class of nucleophilic molecular hydrides capable of addition to a variety of substrates. They can be turned over with terminal reductants and emerged over the last few years as powerful and versatile catalysts ...

2020

Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Florian Maria Wurm

In the last three decades, protein yields from recombinant CHO cells in bioreactors have increased 10-100 fold, as the result of improvements in media, bioprocess design and cell culture process control. The contribution of expression vector constructs and ...

Wiley2016