Pde-Constrained Optimization For Nuclear Mechanics

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The endoplasmic reticulum (ER) extends to the outer (ONM) and the inner (INM) nuclear membrane forming the nuclear envelope (NE) that delimits the nucleoplasm containing the cell genome. Unfolded protein responses (UPRs) and reticulophagy responses increas ...

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

Prediction of ground motion triggered by earthquakes is a prime concern for both the seismology community and geotechnical earthquake engineering one. The subfield occupied with such a problem is termed site response analysis (SRA), its one-dimensional fla ...

The local physical properties - such as shape and flexibility - of the DNA double-helix is today widely believed to be influenced by nucleic acid sequence in a non-trivial way. Furthermore, there is strong evidence that these properties play a role in many ...

Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses. The DNA sensor cyclic ...

The past decades have seen numerous efforts to apply the finite volume methodology to solid mechanics problems. However, only limited work has been done by the finite volume community toward the simulation of mechanical contact. In this article, we present ...

Mycobacteria have unique cell envelopes, surface properties and growth dynamics, which all play a part in the ability of these important pathogens to infect, evade host immunity, disseminate and to resist antibiotic challenges. Recent atomic force microsco ...

The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...

Porous brittle solids evidence complex mechanical behavior, where localized failure patterns originate from mechanical processes on the microstructural level. In order to investigate the failure mechanics of porous brittle solids, we outline a general stoc ...

In this work, we present the development of a 3D lattice-type model at microscale based upon the Voronoi-cell representation of material microstructure. This model can capture the coupling between mechanic and electric fields with non-linear constitutive b ...

Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs. In the cytoplasm, the soluble Nups exist, but how their assembly ...

The inner nuclear membrane is functionalized by diverse transmembrane proteins that associate with nuclear lamins and/or chromatin. When cells enter mitosis, membrane-chromatin contacts must be broken to allow for proper chromosome segregation; yet how thi ...

Atomistic simulations are a bottom up approach that predict properties of materials by modelling the quantum mechanical behaviour of all electrons and nuclei present in a system. These simulations, however, routinely assume nuclei to be classical particles ...

Organelle-specific nanocarriers (NCs) are highly sought after for delivering therapeutic agents into the cell nucleus. This necessitates nucleocytoplasmic transport (NCT) to bypass nuclear pore complexes (NPCs). However, little is known as to how comparabl ...

The propagation of fluid driven fractures is used in a number of industrial applications (well stimulation of unconventional reservoirs, development of deep geothermal systems) but also occurs naturally (magmatic dyke intrusion). While the mechanics of hyd ...

In solid mechanics, linear structures often exhibit (local) nonlinear behavior when close to failure. For instance, the elastic deformation of a structure becomes plastic after being deformed beyond recovery. To properly assess such problems in a real-life ...

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveilla ...

In countries of low to moderate seismicity, such as Switzerland, unreinforced masonry (URM) is mainly used in residential buildings due to its good insulation capacity and fire resistance along with a fair compressive strength. URM walls however show a lim ...

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulatio ...

Pde-Constrained Optimization For Nuclear Mechanics

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Control of nuclear envelope dynamics during acute ER stress by LINC complexes disassembly and selective, asymmetric autophagy of the outer nuclear membrane

Dynamics of CLIMP-63 S-acylation control ER morphology

Data-driven 1D wave propagation for site response analysis

Landscapes of DNA Mechanics and Genomes

Exploring the mechanisms governing nuclear cGAS localization and activity

Data-driven numerical site response

Development of a semi-implicit contact methodology for finite volume stress solvers

Seeing and Touching the Mycomembrane at the Nanoscale

Mechanical principles of engineering fibrous tissues with programmable shape

Computational micromechanics of porous brittle solids

Multi-scale model for coupled piezoelectric-inelastic behavior

Spatial control of nucleoporin condensation by fragile X-related proteins

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

Nuclear Quantum Effects: Fast and Accurate

Organelle-specific targeting of polymersomes into the cell nucleus

Propagation of fluid driven fractures in transversely isotropic material

Model order reduction for large-scale structures with local nonlinearities

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Stiffness, force and drift capacity of in-plane loaded modern unreinforced brick masonry walls

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver