Publication

Comment on : A Validated Model of Cell-Mediated Immune Response to Tumor Growth

Jean-Yves Le Boudec
2007
Journal Articles

Résumé

We found an inconsistency between biological data and some of the initial conditions of the mathematical model of tumor growth in ``A Validated Mathematical Model of Cell- Mediated Immune Response to Tumor Growth'' dePillis2005. We show that correcting this inconsistency changes the conclusion about the effectiveness of NK cells.

Source officielle

https://infoscience.epfl.ch/entities/publication/d6a04404-d336-4d75-aad8-fd6356dc36a6

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Jean-Yves Le Boudec
2007
Journal Articles

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/d6a04404-d336-4d75-aad8-fd6356dc36a6

À propos de ce résultat

Concepts associés (23)

Immunité cellulaire

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

Système immunitaire adaptatif

vignette|Schéma simplifié de l'homéostasie et de la réponse immunitaire au niveau de la barrière intestinale. Le système immunitaire adaptatif comprend les lymphocytes T, qui contribuent à l'immunité à médiation cellulaire, et les lymphocytes B, qui sont responsables de l'immunité à médiation humorale. Ces deux populations cellulaires ont des propriétés et des fonctions distinctes des cellules du système immunitaire inné.

Système immunitaire

vignette|Un lymphocyte, principale composante du système immunitaire adaptatif des vertébrés. Le système immunitaire d'un organisme est un système biologique complexe constitué d'un ensemble coordonné d'éléments de reconnaissance et de défense qui discrimine le soi du non-soi. Ce qui est reconnu comme non-soi est détruit. Il protège l'organisme des agents pathogènes : virus, bactéries, parasites, certaines particules ou molécules « étrangères » (dont certains poisons), mais est responsable du phénomène de rejet de greffe.

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