H-1, C-13 and N-15 assignment of the C-terminal domain of GNA2132 from Neisseria meningitidis

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Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...

Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experiments. Here, we ...

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

Solving native structures of such large molecules, like biomolecules, is often challenging, particularly due to the potentially infinite number of non-covalent interactions with water. In this thesis, we report the use of cold ion gas-phase action spectros ...

Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus's spike protein and ce ...

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test p ...

We investigate the gas-phase structure of the neutral pentaalanine peptide. The IR spectrum in the 340-1820 cm-1 frequency range is obtained by employing supersonic jet cooling, infrared multiphoton dissociation, and vacuum-ultraviolet action spectroscopy. ...

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

Structure determination of materials is key to understanding their physical properties. While single-crystal X-ray diffraction is the gold standard for structures displaying long-range order, many materials of interest are polycrystalline and/or disordered ...

H-1, C-13 and N-15 assignment of the C-terminal domain of GNA2132 from Neisseria meningitidis

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Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy

Screening for drivers of SARS-CoV-2 uptake

Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Indication of 310-Helix Structure in Gas-Phase Neutral Pentaalanine

Dynamics of CLIMP-63 S-acylation control ER morphology

NMR Crystallography in the Big Data Era: New Methods and Applications Powered by Machine Learning