Benzothiazinones: from a new lead to new combination therapies against Mycobacterium tuberculosis

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The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

Johan Auwerx

The constant expansion of the field of metabolic research has led to more nuanced and sophisticated understanding of the complex mechanisms that underlie metabolic functions and diseases. Collaborations with scientists of various fields such as neuroscienc ...

NATURE PORTFOLIO2025

Identification of polypharmacy patterns in new-users of metformin using the Apriori algorithm: A novel framework for investigating concomitant drug utilization through association rule mining

Guillaume Romain Obozinski

Purpose: With increased concomitant chronic diseases in type 2 diabetes mellitus (T2DM), the use of multiple drugs increases as well as the risk of drug-drug interac-tions (DDI) and adverse drug reactions (ADR). Nevertheless, how medication patterns vary i ...

2023

Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

Jörg Hülsken, Maxim Norkin

Background We propose a new approach for designing personalized treatment for colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical modeling of the results. ...

BMC2023

Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma

Paul Joseph Dyson

Simple Summary In this study, drug combination screening was used to design a multidrug combination consisting of repurposed drugs to treat sunitinib-resistant clear cell renal cell carcinoma. In the frame of this project, the multidrug combination has bee ...

MDPI2021