Proteomics and circadian rhythms: It's all about signaling!

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Earth rotation around its axis imposes a 24-hour rhythmicity to all life on the planet. Rather than passively responding to these periodic changes, nature has given us an internal timekeeper, the circadian clock, to anticipate to our advantage the fluctuat ...

The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an a ...

Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...

Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...

The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

Efficient numerical simulations of coupled multi-component systems can be particularly challenging. This is mostly due to the complexity of their solutions, as mutual interactions may cause emergent behaviors, including synchronization and instabilities. V ...

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

The Bio Image and Signal Processing (BISP) Technical Committee (TC) of the IEEE Signal Processing Society (SPS) promotes activities within the broad technical field of biomedical image and signal processing. Areas of interest include medical and biological ...

Epilepsy is a common chronic neurological disorder that causes recurring seizures and affects more than 50 million people worldwide. Implantable medical devices (IMDs) are regarded as effective tools to cure patients who suffer from refractory epilepsy. Se ...

The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to sense surfaces and contro ...

Recently, we published an article [1] presenting how the Power Electronics course at the bachelor level is organized by the Power Electronics Laboratory and taught at Ecole Polytechnique Fédérale de Lausanne, EPFL, Switzerland. For those avid readers who m ...

Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...

The ipRGCs in the human eye mediate several effects on people, such as alertness and circadian rhythms. The spectral, temporal and spatial characteristics of light influence the magnitude of these effects. To facilitate the anticipation of the ipRGC-influe ...

Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual ...

Improving indoor lighting conditions at the workplace has the potential to support proper circadian entrainment of hormonal rhythms, sleep, and well-being. We tested the effects of optimized dynamic daylight and electric lighting on circadian phase of mela ...

Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian regulation of lipid metabolism in ...

In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of ...

Recent advances in biology and neuroscience have elucidated pathways in which visible light initiates a signaling process, via the eye, responsible for activating direct and indirect biological responses. While the full impact of unnatural light patterns o ...

Community structure in graph-modeled data appears in a range of disciplines that comprise network science. Its importance relies on the influence it bears on other properties of graphs such as resilience, or prediction of missing connections. Nevertheless, ...

Proteomics and circadian rhythms: It's all about signaling!

Chattez avec Graph Search

Statistical physics of periodic biological processes

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling

The circadian clock time tunes axonal regeneration

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Reduced order models for coupled systems

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

From Nano to Macro An overview of the IEEE Bio Image and Signal Processing Technical Committee

Hardware Implementation of Digital Signal Processing Algorithms for Programmable Epilepsy Control Systems

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

Learning With Your PETS

Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation

A simulation tool for building and lighting design considering ipRGC-influenced light responses

Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia

Optimized office lighting advances melatonin phase and peripheral heat loss prior bedtime

Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets

Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

Theory and application of a data-driven approach to compressive spectrometry in the assessment of neurophotic stimulation

Graph signal processing tailored for subgraph focus and community structure