Radiobiology of Radiosurgery for Neurosurgeons

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The LHCb experiment at CERN has been upgraded for the Run 3 operation of the Large Hadron Collider (LHC). A new concept of tracking detector based on Scintillating Fibres (SciFi) read out with multichannel silicon photomultipliers (SiPMs) was installed dur ...

A portable opto-electronic device test bench together with a neutron irradiation setup at Reactor Argentino 1 (RA-1) facility in Buenos Aires (Argentina) is presented. The irradiation with neutrons is performed to reproduce the expected damage the devices ...

Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of both tumour and microenvironmental structures 1-3 . This has enabled better modelling of low-complexity cancer ...

In the design of delivery strategies for anticancer therapeutics, the controlled release of intact cargo at the destined tumor and metastasis locations is of particular importance. To this end, stimuli-responsive chemical linkers have been extensively inve ...

Identifying individuals who are at high risk of cancer due to inherited germline mutations is critical for effective implementation of personalized prevention strategies. Most existing models focus on a few specific syndromes; however, recent evidence from ...

Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing ...

In this paper, the total ionizing dose (TID) response of a commercial 28-nm high-k CMOS technology at ultrahigh doses is measured and discussed. The degradation of pMOSFETs depends not only on the channel width but also on the channel length. Short-channel ...

High-risk human papillomavirus (HPV) are responsible for genital and oral cancers associated with the expression of the E6/E7 HPV oncogenes. Therapeutic vaccines targeting those oncogenes can only partially control tumor progression, highlighting the neces ...

Compositions and methods for modulating innate and adaptive immunity and for use in immunotherapy are disclosed. In particular, the invention relates to novel ganciclovir derivatives and methods of using them for the treatment of immune-related disorders, ...

Various studies have attributed NF-kB activation to promote KRAS mediated non-small cell lung cancer progression. In order to identify key genes regulating NF-kB activation and cell survival in lung adenocarcinoma, a synthetic lethal partner screen for KRA ...

Glioma models have provided important insights into human brain cancers. Among the investigative tools, MRI has allowed their characterization and diagnosis. In this study, we investigated whether diffusion MRI might be a useful technique for early detecti ...

Phase contrast x-ray imaging (PCXI) is a promising imaging modality, capable of sensitively differentiating soft tissue structures at high spatial resolution. However, high sensitivity often comes at the cost of a long exposure time or multiple exposures p ...

To detect bronchial carcinoma by autofluorescence, we measured the spectra of tumor and normal tissue in situ, in an in vivo model and in vitro by fiber optic spectrometer and two-dimensional resolved microspectroscopy. The in situ measurements were perfor ...

Radiobiology of Radiosurgery for Neurosurgeons

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Cryogenic Operation of Silicon Photomultiplier Arrays

Simultaneous Irradiation and Testing for Radiation Damage Evaluation in Actively Biased SiPMs and Other Devices

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

Smart chemistry for traceless release of anticancer therapeutics

Multi-syndrome, multi-gene risk modeling for individuals with a family history of cancer with the novel R package PanelPRO

Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers

Influence of Halo Implantations on the Total Ionizing Dose Response of 28-nm pMOSFETs Irradiated to Ultrahigh Doses

Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors

Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy

Role of RIP4 in lung adenocarcinoma differentiation

Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T

A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer

Autofluorescence detection of tumors in the human lung - spectroscopical measurements in situ, in an in vivo model and in vitro