Publications associées à Improved Physiochemical Properties of Chitosan@PCL Nerve Conduits by Natural Molecule Crosslinking

A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length

Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A nov ...

Wiley2023

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

Silvestro Micera

When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the ner ...

MDPI2023

Controlling the Microstructure and Composition of 3D Printed Soft Load-Bearing Hydrogels

Matteo Hirsch

Hydrogels are among the first materials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot bear significa ...

EPFL2023

Targeted regeneration of spinal cord neurons across a complete injury restores walking

Marco Milano

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

EPFL2023

Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Background: Neurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a frequent complication often leading to erectile tissue remodeling and permanent ED. Low-intensity electrostimulation (LIES) has been shown to enhance peripheral nerv ...

ELSEVIER SCI LTD2022

Mechanical Reinforcement of Hydrogels through Physical Crosslinks and Double Network Granular Architecture

Alvaro Lino Boris Charlet

Throughout nature, organisms fabricate a myriad of materials to sustain their lifestyle. Many of the soft materials are composed of water-swollen networks of organic molecules, so-called hydrogels. They generally contribute to the mechanical integrity of t ...

EPFL2022

All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes

Silvestro Micera

Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Here, we present and test in animal models a new regenerative nerve cuff electrode (RnCE). It is based on a novel low-cost fabri ...

FRONTIERS MEDIA SA2021

Axon regeneration and circuit reorganization after complete spinal cord injury

Sabry Leonardo Barlatey

First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant functional benefits can be achieved with lumbosacral neuromodulation and reorganized spared projections. However, complete spinal cord injuries (SCI) wholly ...

EPFL2019

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury

Nicholas David James

We recently discovered a novel role for neuregulin-1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional ...

2019

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Claudia Kathe, Thomas Haynes Hutson

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Required growth facilitators propel axon regeneration across complete spinal cord injury

Sabry Leonardo Barlatey, Grégoire Courtine, Cheng Wang, Mark Andrew Anderson, Michael V. Sofroniew, Zhigang He, Nicholas David James

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Influencing axon regeneration after spinal cord injury

Mark Andrew Anderson

Spinal cord injury (SCI) results in a severing of axonal connections that leads to permanent sensorimotor deficits. In cases of incomplete injury, rehabilitation paradigms have been reported to be successful in improving behavioral outcome in humans with S ...

EPFL2017

Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

Silvestro Micera

Objective. As artificial prostheses become more refined, they are most often used as a therapeutic option for hand amputation. By contrast to extra- or intraneural interfaces, regenerative nerve electrodes are designed to enable electrical interfaces with ...

Iop Publishing Ltd2017

In vitro evaluation of gel-encapsulated adipose derived stem cells: Biochemical cues for in vivo peripheral nerve repair

Stéphanie Lacour

Adipose‐derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast‐growing and able to protect neurons from apoptosis; they can reduce postinjury latency and the risk of muscle atrophy. This study evalua ...

Wiley-Blackwell2017

Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors

Silvestro Micera, Daniel Santos

After peripheral nerve injury, motor and sensory axons are able to regenerate but inaccuracy of target reinnervation leads to poor functional recovery. Extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert their effect on different ne ...

2017

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Silvestro Micera, Daniel Santos

Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. In this study, PLGA microsph ...

Elsevier Science Bv2016

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Biodegradable HEMA-based hydrogels with enhanced mechanical properties

Dominique Pioletti, Mohamadreza Nassajian Moghadam

Hydrogels are widely used in the biomedical field. Their main purposes are either to deliver biological active agents or to temporarily fill a defect until they degrade and are followed by new host tissue formation. However for this latter application, bio ...

Wiley-Blackwell2016

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin, Lin Jin

Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter ...

Elsevier2015

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

Cédric Xavier Paulou

Regenerative peripheral nerve interfaces are particularly invasive implant devices. They rely on the growth of axons from transected nerve stumps through electrode-bearing structures in order to establish highly efficient communication channels with the ne ...

EPFL2015