Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

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Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...

The melanization response is an important defense mechanism in arthropods. This reaction is mediated by phenoloxidases (POs), which are activated by complex extracellular serine protease (SP) cascades. Here, we investigate the role of SPs in the melanizati ...

In the past two decades, the use of ontologies has been proven to be an effective tool for enriching existing information systems in the digital data modelling domain and exploiting those assets for semantic interoperability. With the rise of Industry 4.0, ...

The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...

The melanization reaction is a rapid and important immune mechanism in arthropods. It results in the production of melanin at the site of injury and around invading microbes. The enzymes responsible for melanogenesis are phenoloxidases (PO), which catalyze ...

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

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Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

HLA tapasin independence: broader peptide repertoire and HIV control

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

A Method for Converting Current Data to RDF in the Era of Industry 4.0

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

The melanization reaction in Drosophila: More than black or white