Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

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Truthful, Transparent and Fair Data Collection Mechanisms

Naman Goel

An important prerequisite for developing trustworthy artificial intelligence is high quality data. Crowdsourcing has emerged as a popular method of data collection in the past few years. However, there is always a concern about the quality of the data thus ...

EPFL2020

Data for Urban Scale Building Energy Modelling: Assessing Impacts and Overcoming Availability Challenges

François Maréchal

Data are essential to urban building energy models and yet, obtaining sufficient and accurate building data at a large-scale is challenging. Previous studies have highlighted that the data impact on urban case studies has not been sufficiently discussed. T ...

2020

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

PUBLIC LIBRARY SCIENCE2020

HLA tapasin independence: broader peptide repertoire and HIV control

Jacques Fellay

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...

National Academy of Sciences2020

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

Bruno Lemaitre, Mark Austin Hanson, Jan Paul Dudzic, Igor Iatsenko

The melanization response is an important defense mechanism in arthropods. This reaction is mediated by phenoloxidases (POs), which are activated by complex extracellular serine protease (SP) cascades. Here, we investigate the role of SPs in the melanizati ...

2019

A Method for Converting Current Data to RDF in the Era of Industry 4.0

Dimitrios Kyritsis, Foivos Psarommatis Giannakopoulos, Damiano Nunzio Arena, Ioannis Tourkogiorgis, Marlène Hildebrand-Ehrhardt

In the past two decades, the use of ontologies has been proven to be an effective tool for enriching existing information systems in the digital data modelling domain and exploiting those assets for semantic interoperability. With the rise of Industry 4.0, ...

SPRINGER INTERNATIONAL PUBLISHING AG2019

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Johan Auwerx, Evan Graehl Williams

The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...

2019

The melanization reaction in Drosophila: More than black or white

Jan Paul Dudzic

The melanization reaction is a rapid and important immune mechanism in arthropods. It results in the production of melanin at the site of injury and around invading microbes. The enzymes responsible for melanogenesis are phenoloxidases (PO), which catalyze ...

EPFL2018

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Pierpaolo Ginefra

Proprotein Convertases (PCs) constitute a family of serine proteases that activate various hormones, growth factors and cell adhesion molecules by mediating endoproteolytic cleavage of their secreted inactive precursors during their transit in the secret ...

EPFL2018