Publications associées à A template for constructing Bayesian networks in forensic biology cases when considering activity level propositions

Opportunities and challenges in design and optimization of protein function

Bruno Emanuel Ferreira De Sousa Correia, Casper Alexander Goverde

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

Nature Portfolio2024

Intermediate Address Space: virtual memory optimization of heterogeneous architectures for cache-resident workloads

David Atienza Alonso, Marina Zapater Sancho, Luis Maria Costero Valero, Darong Huang, Qunyou Liu

The increasing demand for computing power and the emergence of heterogeneous computing architectures have driven the exploration of innovative techniques to address current limitations in both the compute and memory subsystems. One such solution is the use ...

2024

Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations

Felix Naef, Pierre Vandergheynst, Cédric Gobet, Mohan Vamsi Nallapareddy, Francesco Craighero

Translation elongation plays an important role in regulating protein concentrations in the cell, and dysregulation of this process has been linked to several human diseases. In this study, we use data from ribo-seq experiments to model ribosome densities, ...

PMLR2024

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Zhidian Zhang

Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

EPFL2024

Toroidal families and averages of L-functions, I

Philippe Michel

We initiate the study of certain families of L-functions attached to characters of subgroups of higher-rank tori, and of their average at the central point. In particular, we evaluate the average of the values L( 2 1 , chi a )L( 21 , chi b ) for arbitrary ...

Polish Acad Sciences Inst Mathematics-Impan2024

Evaluation and digitalization: what are the key challenges for evaluation processes and evaluators?

Omar Ballester Gonzalez

Public policy evaluation has traditionally been conducted in a context constrained by legal, institutional and political red tape. The arrival of digitalisation adds a new layer to public policy evaluation processes. Assessing the quality of technologies, ...

Edward Elgar Publishing2023

Periodic and aperiodic NiFe nanomagnet/ferrimagnet hybrid structures for 2D magnon steering and interferometry with high extinction ratio

Dirk Grundler, Vinayak Shantaram Bhat, Sho Watanabe, Andrea Mucchietto, Shixuan Shan, Elif Nur Dayi

File formats are described in read_me files in the concerning folder. For plotting and data evaluation, Python 2.7 was used. Example scripts for plotting are provided. ...

Zenodo2023

Towards Novel Evaluation Methods for Social Dialog Systems

Ekaterina Svikhnushina

Language has shaped human evolution and led to the desire to endow machines with language abilities. Recent advancements in natural language processing enable us to achieve this breakthrough in human-machine interaction. However, introducing conversational ...

EPFL2023

Entrepreneurial Opportunities and Threats in the Era of Grand Societal Challenges

Enrico Bergamini

We live in an era defined by attempts to grapple with an ever-expanding array of grand societal challenges (GCs). These challenges comprise transformational social and environmental issues, such as environmental degradation and global pandemics, and the cr ...

EPFL2023

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Ece Uslu

Tantalum is receiving increasing attention in the biomedical field due to its biocompatible nature and superior mechanical properties. However, the bioinert nature of tantalum still poses a challenge and limits its integration into the bone tissue. To addr ...

Amer Chemical Soc2023

Rebooting Virtual Memory with Midgard

Siddharth Gupta

Virtual Memory (VM) is a critical programming abstraction that is widely used in various modern computing platforms. With the rise of datacenter computing and birth of planet-scale online services, the semantic and capacity requirements from memory have ev ...

EPFL2023

Structural Insights into Electrophiles and Electrophilic Metabolites Sensing and Signaling: The Missing Information

Chloé Rogg, Yimon Aye

Native reactive electrophilic species (RES) are long-recognized regulators of pathophysiology; yet, knowledge surrounding how RES regulate context-specific biology remains limited. The latest technological advances in profiling and precision decoding of RE ...

WILEY-V C H VERLAG GMBH2023

Computational conceptual design — typological exploration of spatial truss systems through optimization

Corentin Jean Dominique Fivet, Jonas Warmuth, Pierluigi D'Acunto

Exploring a wide range of design options is crucial for every sound conceptual design process. In the conventional structural design workflow, optimization techniques are generally employed to generate well-performing design options. However, focusing only ...

International Association for Shell and Spatial Structures (IASS)2023

Development of a Robotic Microsurgeon for Embryonic Research

Ece Özelçi

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

EPFL2023

A Geometric Transformer for Structural Biology: Development and Applications of the Protein Structure Transformer

Lucien Fabrice Krapp

Proteins, the central building blocks of life, play pivotal roles in nearly every biological function. To do so, these macromolecular structures interact with their surrounding environment in complex ways, leading to diverse functional behaviors. The predi ...

EPFL2023

1(st) Workshop on Maritime Computer Vision (MaCVi) 2023: Challenge Results

Alexandre Massoud Alahi, Christophe De Vleeschouwer, Alexandre Bernardino, Yang Song, Siddharth Gupta

The 1st Workshop on Maritime Computer Vision (MaCVi) 2023 focused on maritime computer vision for Unmanned Aerial Vehicles (UAV) and Unmanned Surface Vehicle (USV), and organized several subchallenges in this domain: (i) UAV-based Maritime Object Detection ...

IEEE COMPUTER SOC2023

De novo protein design by inversion of the AlphaFold structure prediction network

Bruno Emanuel Ferreira De Sousa Correia, Stéphane Rosset, Casper Alexander Goverde, Benedict Dieter Gregor Wolf, Hamed Khakzad

De novo protein design enhances our understanding of the principles that govern protein folding and interactions, and has the potential to revolutionize biotechnology through the engineering of novel protein functionalities. Despite recent progress in comp ...

2023

Crystalline or amorphous? A critical evaluation of phenomenological phase selection rules

Johann Michler, Ashish Sharma, Caroline Hain

In this work, we reviewed the available phase selection rules comprising atomic size and topological aspects, entropies, enthalpies, melting points, valence and itinerant electron concentrations, as well as electronegativity, and validated them using a car ...

ELSEVIER SCI LTD2023

From finger animation to full-body embodiment of avatars with different morphologies and proportions

Mathias Guy Delahaye

VR (Virtual Reality) is a real-time simulation that creates the subjective illusion of being in a virtual world. This thesis explores how integrating the user's body and fingers can be achieved and beneficial for the user to experience VR. At the advent of ...

EPFL2023

Formula Normalizations in Verification

Viktor Kuncak, Mario Bucev, Simon Guilloud, Dragana Milovancevic

We propose a new approach for normalization and simplification of logical formulas. Our approach is based on algorithms for lattice-like structures. Specifically, we present two efficient algorithms for computing a normal form and deciding the word problem ...

2023