Publications associées à The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Yogesh Singh Chauhan, Hilal Lashuel, Florian Lang, Joan Romani Aumedes, Yogesh Singh

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

BMC2023

Community-Aware Group Testing

Suhas Diggavi, Christina Fragouli, Pavlos Nikolopoulos, Sundara Rajan Srinivasavaradhan

Group testing is a technique that can reduce the number of tests needed to identify infected members in a population, by pooling together multiple diagnostic samples. Despite the variety and importance of prior results, traditional work on group testing ha ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2023

Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Anthony Pierre Robert Renard

Rodents depend on olfaction and touch to meet many of their fundamental needs. However, the impact of simultaneous olfactory and tactile inputs on sensory representations in the cortex remains elusive. To study these interactions, we recorded large populat ...

Nature Portfolio2022

Group testing for connected communities

Suhas Diggavi, Christina Fragouli, Pavlos Nikolopoulos, Sundara Rajan Srinivasavaradhan

In this paper, we propose algorithms that leverage a known community structure to make group testing more efficient. We consider a population organized in disjoint communities: each individual participates in a community, and its infection probability depe ...

MICROTOME PUBLISHING2021

Shedding light on excessive crying in babies

Dimitri Nestor Alice Van De Ville, François Lazeyras, Lorena Gonçalves de Alcântara e Freitas Krikler

Background Excessive and inconsolable crying behavior in otherwise healthy infants (a condition called infant colic (IC)) is very distressing to parents, may lead to maternal depression, and in extreme cases, may result in shaken baby syndrome. Despite the ...

NATURE PUBLISHING GROUP2021

Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations

Philippe Renaud, Thamani Dahoun, Margaux Catherine Marie Duchamp, George Coukos, Alexandre Harari, Marion Arnaud

In this study we present a novel microfluidic hydrodynamic trapping device to probe the cell–cell interaction between all cell samples of two distinct populations. We have exploited an hydrodynamic trapping method using microfluidics to immobilize a batch ...

2019

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Horst Vogel, Horst Pick, Thamani Dahoun, Shuguang Yuan, Marc Brugarolas Campillos

The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of most ORs have not yet been identified and potential non-olfactory processes m ...

Springer2019

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

Freddy Radtke

Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To ...

2018

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Matteo Dal Peraro, Benoîte Bargeton

Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Mori ...

Elsevier2017

Subject-Independent Odor Pleasantness Classification Using Brain and Peripheral Signals

Touradj Ebrahimi, Jean-Marc Vesin, Eleni Kroupi

Enhanced sensation of reality from multimedia contents can be achieved by creating realistic multimedia environments, using visual, auditory, and olfactory information. Although the affective information from video and audio has been extensively studied, t ...

Ieee-Inst Electrical Electronics Engineers Inc2016

Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae

Philippe Renaud

Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversio ...

Nature Publishing Group2016

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Vogel, Horst Pick, Olivia Baud, Luc Veya, Shuguang Yuan

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

Fluctuation-driven neural dynamics reproduce Drosophila locomotor patterns

Dario Floreano, Andrea Maesani, Pavan P Ramdya, Kyle Gustafson

The neural mechanisms determining the timing of even simple actions, such as when to walk or rest, are largely mysterious. One intriguing, but untested, hypothesis posits a role for ongoing activity fluctuations in neurons of central action selection circu ...

2015

Automatic Hand Phantom Map Detection Methods

Christian Enz, Claudio Bruschini, Jörn Justiz, Huaiqi Huang, Tao Li

Many amputees have maps of referred sensation from their missing hand on their residual limb (phantom maps). This skin area can serve as a target for providing amputees with tactile sensory feedback. Providing tactile feedback on the phantom map can improv ...

2015

Phase-based manganese enhanced MRI, a new methodology to enhance brain cytoarchitectural contrast and study manganese uptake

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Rajika Maddage

Purpose As the magnetic susceptibility induced frequency shift increases linearly with magnetic field strength, the present work evaluates manganese as a phase imaging contrast agent and investigates the dose dependence of brain enhancement in comparison t ...

Wiley-Blackwell2014

Emergence of Connectivity Motifs in Networks of Model Neurons with Short- and Long-Term Plastic Synapses

Michele Giugliano, Eleni Vasilaki

Recent experimental data from the rodent cerebral cortex and olfactory bulb indicate that specific connectivity motifs are correlated with short-term dynamics of excitatory synaptic transmission. It was observed that neurons with short-term facilitating sy ...

Public Library of Science2014

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Liliane Glauser, Graham Knott, Darren Moore, Elpida Tsika, Meghna Kannan, Shi-Yan Caroline Foo

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...

Elsevier2014

Non-Linear EEG Features for Odor Pleasantness Recognition

Touradj Ebrahimi, Eleni Kroupi, Dionisije Sopic

Since olfactory sense is gaining ground in multimedia applications, it is important to understand the way odor pleasantness is perceived. Although several studies have explored the way odor pleasantness perception influences the power spectral density of t ...

2014

Functional Characterization of the Mouse Olfactory Receptor mOR256-17 in Live Cells

Thamani Dahoun

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system to recognize and discriminate a nearly unlimited number of structurally diverse odorant molecules. The molecul ...

EPFL2013

Making Automated Testing of Cloud Applications an Integral Component of PaaS

George Candea, Stefan Bucur, Johannes Kinder

Traditional testing is inadequate for the complexity of modern cloud application software stacks. While the platform-as-a-service (PaaS) model has streamlined application development and deployment, its multiple abstraction layers and dependencies have mad ...

2013