Publication

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

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Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

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Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context

Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia

Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells

Allosteric regulation and targeting of Bruton's tyrosine kinase (Btk) in B-cell lymphoma

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Allosteric kinase inhibitors

Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro

Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia