Photodynamic diagnostics in the urinary tract. Consensus paper of the Working Group for Oncology of the German Society for Urology

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Urinary incontinence (UI) is prevalent and distressing medical condition affecting millions of patients worldwide. Current treatment options for severe cases often involve surgical intervention, such as the implantation of an artificial urinary sphincter ( ...

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

Low urinary tract dysfunctions and symptoms (LUTS) and Urinary incontinence (UI) in particular is a medical condition that affects millions of people worldwide. One of the most promising long term treatments for this condition is the use of an artificial u ...

In the clinic, it is difficult to distinguish the malignancy and aggressiveness of solid pulmonary nodules (PNs). Incorrect assessments may lead to delayed diagnosis and an increased risk of complications. We developed and validated a deep learning-based m ...

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...

In this paper, we consider electric vehicle charging facilities that offer various levels of service, i.e., charging rates, for varying prices such that rational users choose a level of service that minimizes the total cost to themselves including an oppor ...

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses. ...

Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses of tissue composition are challenged by the scale and diversity of the data. Here we pres ...

Uropathogenic Escherichia coli (UPEC) are the most common bacterial pathogens causing urinary tract infections (UTIs). Driven by the development of antibiotic resistant UPEC strains, UTIs have become a major public health issue and generate substantial hea ...

Years of globalization, outsourcing and cost cutting have increased supply chain vulnerability calling for more effective risk mitigation strategies. In our research, we analyze supply chain disruptions in a production setting. Using a bilevel optimization ...

This paper examines the minimization of the cost for an expected random production output, given an assembly of finished goods from two random inputs, matched in two categories. We describe the optimal input portfolio, first using the standard normal appro ...

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related ...

Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...

Lignocellulosic biomass is a potential renewable resource for production of high-value, sustainable products. Furfural is among the important bio-based chemicals in biorefineries. However, the conventional process of furfural production using a reaction-se ...

High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of head and neck squamous-cell carcinoma (HNSCC) and thus therapeutic E7-vaccines may be used to control HPV+HNSCC tumors. Herein we investigated the effects o ...

Globalization, outsourcing and cost optimization have all contributed to increased supply chain vulnerability, yet our understanding of effective mitigation strategies remains limited. In our research, we study the effects of disruptions on supply chain ne ...

BackgroundTotal knee arthroplasty (TKA) is most frequently planned using conventional two-dimensional weight-bearing lower limb radiographs and is performed with conventional femoral and tibial cutting guides. Questions have been raised about the accuracy ...

Photodynamic diagnostics in the urinary tract. Consensus paper of the Working Group for Oncology of the German Society for Urology

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An artificial urinary sphincter based on dielectric elastomer technology

System for micturition control in a mammal with bladder disfunction

Decoding bladder state from pudendal intraneural signals in pigs

Mechanical Characterisation of Porcine Urethra: Non Linear Constitutive Models and Experimental Approach

Deep learning predicts malignancy and metastasis of solid pulmonary nodules from CT scans

Metabolic dependencies of metastasis-initiating cells in female breast cancer

Sensitivity to user mischaracterizations in electric vehicle charging

Systematic benchmarking of single-cell ATAC-sequencing protocols

CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

Modeling and mitigating supply chain disruptions as a bilevel network flow problem

Optimal Matching of Random Parts

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Exergy and exergoeconomic analyses of sustainable furfural production via reactive distillation

Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model

Modeling Supply Chain Disruptions: A Network Flow Approach

Advantages of patient-specific cutting guides with disposable instrumentation in total knee arthroplasty: a case control study