Publication

Continuous and label-free toxicity screening of human hepatocytes on chip reveals frequency-dependant impedance profiles

Publications associées (30)

Forecasting intracranial hypertension using multi-scale waveform metrics

Objective: Acute intracranial hypertension is an important risk factor of secondary brain damage after traumatic brain injury. Hypertensive episodes are often diagnosed reactively, leading to late detection and lost time for intervention planning. A pro-ac ...

IOP PUBLISHING LTD2020

Positional dependence of particles and cells in microfluidic electrical impedance flow cytometry: origin, challenges and opportunities

Philippe Renaud, Jonathan Bastien Cottet

Microfluidic electrical impedance flow cytometry is now a well-known and established method for single-cell analysis. Given the richness of the information provided by impedance measurements, this non-invasive and label-free approach can be used in a wide ...

2020

Single-Phase Measurement of the Output Impedance of the Four-Quadrant Cascaded H-Bridge Converter Cell Using Wideband Signals

Marko Petkovic, Drazen Dujic

The development and integration of power electronics equipment and converters for medium voltage ac and dc application has created different subsystem interactions that require proper investigation, understanding, description and estimation of global syste ...

IEEE2020

A biosensor for measuring NAD(+) levels at the point of care

Kai Johnsson, Luc Patiny, Elena Katsyuba, Johan Auwerx, Qiuliyang Yu, Lin Xue

The cellular level of nicotinamide adenine dinucleotide (NAD(+)), through its different functions, affects cellular metabolism and signalling(1-3). A decrease in the NAD(+) content has been associated with various pathologies and physiological aging(4,5), ...

NATURE PUBLISHING GROUP2019

Engineered peptide macrocycles can inhibit matrix metalloproteinases with high selectivity

Christian Heinis, Jeremy Touati, Maola Khan Mohammad Golam, Michal Sabisz, Alice Baumann, Jonas Alfred Karl Wilbs, Xudong Kong, Kaycie Marie Butler

Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases at the intersection of health and disease due to their involvement in processes such as tissue repair and immunity as well as cancer and inflammation. Because of the high structural conserv ...

2019

Designing Configurable Arm Rehabilitation Games: How Do Different Game Elements Affect User Motion Trajectories?

Pierre Dillenbourg, Thibault Lucien Christian Asselborn, Ayberk Özgür, Arzu Güneysu Özgür, Wafa Monia Benkaouar Johal, Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Jennifer Kaitlyn Olsen

For successful rehabilitation of a patient after a stroke or traumatic brain injury, it is crucial that rehabilitation activities are motivating, provide feedback and have a high rate of repetitions. Advancements in recent technologies provide solutions to ...

IEEE2019

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Francesco Stellacci, Ye Yang, Ahmet Bekdemir

We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads ...

2019

Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood

Hongxia Lei, Yohan Van de Looij

Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures. Such HI injuries may cause lifelong disturbances in the distant regions, such as the contra ...

2019

Artificial niche microarrays for identifying extrinsic cell-fate determinants

Matthias Lütolf, Samy Gobaa

The complex cellular microenvironment plays an important role in determining cell fate. For example, stem cells located in a microenvironment termed niche integrate a wide variety of extrinsic cues to take distinct fate choices. Capturing this multiple-inp ...

ELSEVIER ACADEMIC PRESS INC2018

In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag

Subashika Govindan

The tracing of neuronal cell lineages is critical to our understanding of cellular diversity in the CNS. This protocol describes a fluorescence birth-dating technique to label, track and isolate isochronic cohorts of newborn cells in the CNS in vivo in mou ...

NATURE PUBLISHING GROUP2018