Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

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A promising approach to influence and control the photophysical properties of conjugated polymers is directing their molecular conformation by templating. We explore here the templating effect of single-stranded DNA oligomers (ssDNAs) on cationic polythiop ...

Experimental and theoretical approaches were employed to analyze the static and dynamic mechanical properties of acrylonitrile butadiene styrene (ABS) nanocomposites reinforced with multiwalled carbon nanotube (MWCNT) and nanosilica. Enhanced stiffness and ...

DNA-protein interactions lie at the crux of life's essential processes. As such, various technologies have been developed to characterize these interactions. The distinct advantages of these technologies can be leveraged to study different facets of these ...

Rapid adhesion between tissue and synthetic materials is relevant to accelerate wound healing and to facilitate the integration of implantable medical devices. Most frequently, tissue adhesives are applied as a gel or a liquid formulation. This manuscript ...

Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug discovery projects across the pharmaceutical industry. The majority of reported projects describe the discovery of rever ...

Drug discovery and development are among the most important translational science activities that contribute to human health and wellbeing. However, the development of a new drug is a very complex, expensive, and long process which typically costs 2.6 bill ...

The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...

Designing compounds that bind to the acidic patch of the nucleosome core particle (NCP) is an emerging therapeutic approach that can inhibit the binding of key chromatin factors. Pretreatment of human ovarian carcinoma, A2780, cells with RAPTA-T, an antime ...

Cells are able to perceive complex mechanical cues across both the micro- and nanoscale which can influence their development. Whilst causative effects between surface topography and cellular function can be demonstrated, the variability in materials used ...

For clinical applications, simplicity, high efficiency, and low toxicity are key issues in the design of anti-tumor drugs. In this work, a novel dual-responsive drug self-framed delivery system (DSFDS) with high drug delivery efficiency is proposed based o ...

Organoids allow the recapitulation of intestinal homeostasis and cancerogenesis in vitro; however, RNA sequencing (RNA-seq)-based methods for drug screens are missing. We develop targeted organoid sequencing (TORNADO-seq), a high-throughput, high-content d ...

Continuous assessment of transferable forcefields for molecular simulations is essential to identify their weaknesses and direct improvement efforts. The latest efforts focused on better describing disordered proteins while retaining proper description of ...

The fragment-based approach is a well-established strategy for organic drug discovery. Recent studies have shown that this approach also has considerable potential in medicinal inorganic chemistry, and yet the approach has not been formally described. Here ...

A major step for the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Caenorhabditis elegans is a soil worm that catches the interest of researchers who study ...

Thin polymer films that are able to bind proteins are of great relevance for a wide variety of biosensor and biochip applications. Some of these applications require films that have high protein binding capacities while others call for surfaces that allow ...

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Chattez avec Graph Search

Structural and Photophysical Templating of Conjugated Polyelectrolytes with Single-Stranded DNA

Static and dynamic mechanical properties of nanosilica and multiwalled carbon nanotube reinforced acrylonitrile butadiene styrene composites: theoretical mechanism of nanofiller reinforcement

Establishing a Ternary System for Optical Monitoring of DNA-Protein Interactions with Single-Walled Carbon Nanotubes

Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush Coatings

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Advancing Drug Discovery via Artificial Intelligence

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Crosslinking Allosteric Sites on the Nucleosome Core Particle

Next Generation Cell Culture Tools Featuring Micro- and Nanotopographies for Biological Screening

Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

Assessment of transferable forcefields for protein simulations attests improved description of disordered states and secondary structure propensities, and hints at multi-protein systems as the next challenge for optimization

Extrapolating the Fragment-Based Approach to Inorganic Drug Discovery

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip

Polymer brush interfaces for protein biosensing prepared by surface-initiated controlled radical polymerization