Publication

Bile acid-FXR alpha pathways regulate male sexual maturation in mice

Publications associées (28)

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Ayyakkannu Ayyanan, Maria Gutierrez Najera, Tamara Tanos, Georgios Sflomos, Maryse Fiche

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis

Johan Auwerx

BACKGROUND & AIMS: Bile reflux contributes to development of Barrett's esophagus (BE) and could be involved in its progression to esophageal adenocarcinoma (EAC). We investigated whether bile acids affect levels or functions of microRNAs (MIRs) 221 and 222 ...

Elsevier2013

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

Alexandre Gattiker

Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and prim ...

Oxford University Press2012

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility

Friedrich Beermann, Anne Wilson, Roman Chrast, Jian Wang

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...

2012

Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

Cathrin Brisken, Ayyakkannu Ayyanan, Jacques Rougemont, Tamara Tanos, Christina Schrick

Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently utilize ...

Endocrine Society2011

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Detection of neuronal activity and metabolism in a model of dehydration-induced anorexia in rats at 14.1T using manganese-enhanced MRI and 1H MRS

Rolf Gruetter, Nathalie Just

In this study, hypothalamic activation was performed by dehydration-induced anorexia (DIA) and overnight food suppression (OFS) in female rats. The assessment of the hypothalamic response to these challenges by manganese-enhanced MRI showed increased neuro ...

Wiley-Blackwell2011

Serotonin, pregnancy and increased autism prevalence: Is there a link?

Nouchine Hadjikhani

The prevalence of autism, a neurodevelopmental condition resulting from genetic and environmental causes, has increased dramatically during the last decade. Among the potential environmental factors, hyperserotonemia during pregnancy and its effect on brai ...

2010