Ricca's factors as mobile proteinaceous effectors of electrical signaling

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Multimeric membrane proteins are produced in the endoplasmic reticulum and transported to their target membranes which, for ion channels, is typically the plasma membrane. Despite the availability of many fully assembled channel structures, our understandi ...

Amino acid availability is monitored by animals to adapt to their nutritional environment. Beyond gustatory receptors and systemic amino acid sensors, enteroendocrine cells (EECs) are believed to directly percept dietary amino acids and secrete regulatory ...

The probability of detecting technosignatures (i.e., evidence of technological activity beyond Earth) increases with their longevity, or the time interval over which they manifest. Therefore, the assumed distribution of longevities has some bearing on the ...

Professionals in the building design and operation fields typically look at standards and guidelines as a reliable source of information and guidance with regard to procedural, contractual, and legal scope and requirements that are relevant to accountabili ...

The performance of modern object detectors drops when the test distribution differs from the training one. Most of the methods that address this focus on object appearance changes caused by, e.g., different illumination conditions, or gaps between syntheti ...

Minimax-fair machine learning minimizes the error for the worst-off group. However, empirical evidence suggests that when sophisticated models are trained with standard empirical risk minimization (ERM), they often have the same performance on the worst-of ...

The NA62 experiment at CERN, designed to study the ultra-rare decay K+ -> pi(+) nu(nu) over bar, has also collected data in beam-dump mode. In this configuration, dark photons may be produced by protons dumped on an absorber and reach a decay volume beginn ...

Parliament dynamics might seem erratic at times. Predicting future voting patterns could support policy design based on the simulation of voting scenarios. The availability of open data on legislative activities and machine learning tools might enable such ...

Ridesourcing has driven a lot of attention in recent years with the expansion of companies like Uber, Lift, and many others around the world. Companies use mobile applications connected through the internet to match drivers and their passengers real-time. ...

The presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the prog-esterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor-positive (ER+) breast cancer characterized ...

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Regulation of mitochondrial redox balance is emerging as a key event for cell signaling in both physiological and pathological conditions. However, the link between the mitochondrial redox state and the modulation of these conditions remains poorly defined ...

To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

Elastic interfaces display scale-invariant geometrical fluctuations at sufficiently large lengthscales. Their asymptotic static roughness then follows a power-law behavior, whose associated exponent provides a robust signature of the universality class to ...

Intracortical brain-machine interfaces decode motor commands from neural signals and translate them into actions, enabling movement for paralysed individuals. The subjective sense of agency associated with actions generated via intracortical brain-machine ...

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

Biophysical models of diffusion in white matter have been center-stage over the past two decades and are essentially based on what is now commonly referred to as the "Standard Model" (SM) of non-exchanging anisotropic compartments with Gaussian diffusion. ...

This paper analyzes efficiency and profitability in the Swiss banking sector over the period 1997–2019. We find strong evidence for scale economies: for most banks in the sample, efficiency and profitability increase with bank size. Using an instrumental v ...

Selective area epitaxy (SAE) provides the path for scalable fabrication of semiconductor nanostructures in a device-compatible configuration. In the current paradigm, SAE is understood as localized epitaxy, and is modelled by combining planar and self-asse ...

Ricca's factors as mobile proteinaceous effectors of electrical signaling

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Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

Technosignatures Longevity and Lindy's Law

Thermal Conditions in Indoor Environments: Exploring the Reasoning behind Standard-Based Recommendations

Learning Transformations To Reduce the Geometric Shift in Object Detection

When do Minimax-fair Learning and Empirical Risk Minimization Coincide?

Search for dark photon decays to μ+μ- at NA62

Predicting party switching through machine learning and open data

Modeling and Optimization of Ridesplitting Operations

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Striatal Dopamine Signals and Reward Learning

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

Representing stimulus information in an energy metabolism pathway

Microscopic interplay of temperature and disorder of a one-dimensional elastic interface

Sense of agency for intracortical brain-machine interfaces

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Neurite Exchange Imaging ((NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

Scale effects on efficiency and profitability in the Swiss banking sector

Selective area epitaxy of GaAs: the unintuitive role of feature size and pitch