Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

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The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

Microorganisms, encompassing both uni- and multicellular entities, exhibit remarkable diversity as omnipresent life forms in nature. They play a pivotal role by supplying essential components for sustaining biological processes across diverse ecosystems, i ...

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

Context. Gaia DR3 has offered the scientific community a remarkable dataset of approximately one million spectra acquired with the radial velocity spectrometer (RVS) in the calcium II triplet region, which is well suited to identify very metal-poor (VMP) s ...

The space industry has experienced substantial growth in recent years, leading to rapid advancements in space exploration and space-based technologies. Consequently, the study of electronics and sensor performance in extreme environments has become crucial ...

An efficient characterization of scientifically significant locations is essential prior to the return of humans to the Moon. The highest resolution imagery acquired from orbit of south-polar shadowed regions and other relevant locations remains, at best, ...

The extent of littoral influence on lake gas dynamics remains debated in the aquatic science community due to the lack of direct quantification of lateral gas transport. The prevalent assumption of diffusive horizontal transport in gas budgets fails to exp ...

Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

Preventing the misfolding or aggregation of transactive response DNA binding protein with 43 kDa (TDP-43) is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis and other neurodegenerative diseases. In this work, we ...

The shapes of galaxies, their outer regions in particular, are important guideposts to their formation and evolution. In this work, we report on the discovery of strongly box-shaped morphologies of the otherwise well-studied elliptical and lenticular galax ...

Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experiments. Here, we ...

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof. ...

The first generation of S-band injectors for free-electron lasers has illustrated high reliability and performance by driving the latest generation of high brightness machines. However, the ultimate electron beam brightness of these devices is limited by t ...

The coevolution of hydrogen and oxygen during photocatalytic water splitting presents a challenge for efficient product separation. Here, we demonstrate membrane-free, drop-based photocatalytic water splitting with inherent product separation and competiti ...

The photochemical thiol-ene reaction is an efficient method for rapid and chemoselective formation of thioether linkages under mild conditions. It has found widespread use in small-molecule synthesis as well as peptide and protein chemistry. While high-thr ...

There is a growing recognition that electronic band structure is a local property of materials and devices, and there is steep growth in capabilities to collect the relevant data. New photon sources, from small-laboratory-based lasers to free electron lase ...

Investigating the dynamic activities of protein expression and signaling in living organisms is a crucial focus of intense research aimed at elucidating the processes that underlie disease progression and improving treatments and drug development. Resolvin ...

Carbon dioxide generated by the human body and exhaled (VCO2) is commonly used for ventilation controls, while the metabolic rate (i.e., energy expenditure EE) is an important parameter defining human thermal comfort in buildings. These two parameters are ...

A search for the rare eta -> mu(+)mu(-)mu(+)mu(-) double-Dalitz decay is performed using a sample of proton-proton collisions, collected by the CMS experiment at the CERN LHC with high-rate muon triggers during 2017 and 2018 and corresponding to an integra ...

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Chattez avec Graph Search

Improved microfluidic transcriptome based screening methods

Microfluidic systems for infectious disease diagnostics

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Gaia's brightest very metal-poor (VMP) stars Metallicity catalogue of a thousand VMP stars from Gaia's radial velocity spectrometer spectra

Single-Photon Avalanche Diode Image Sensors for Harsh Radiation Environments

A lunar reconnaissance drone for cooperative exploration and high-resolution mapping of extreme locations

Lake surface cooling drives littoral-pelagic exchange of dissolved gases

Methods for high-throughput synthesis and screening of peptide libraries

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

The Halos and Environments of Nearby Galaxies (HERON) survey IV. Complexity in the boxy galaxies NGC720 and NGC2768

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Method for hormone or drug screening in a tissue sample

Toward a brightness upgrade to the SwissFEL: A high gradient traveling-wave rf photogun

Single emulsion drops for photocatalytic water splitting as a membrane-free approach to product separation

Nanomole-scale photochemical thiol-ene chemistry for high-throughput late-stage diversification of peptide macrocycles

Transfer learning application of self-supervised learning in ARPES

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Inter- and intra-individual variability in CO2 production and metabolic rate

Observation of the Rare Decay of the η Meson to Four Muons