Publication

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Publications associées (30)

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

In a number of cardiovascular diseases, the paucity of longitudinal human data hinders our understanding of disease evolution and forestalls the discovery of new therapeutic strategies. We therefore heavily rely on animal models to elucidate the mechanisms ...

EPFL2019

Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Paul Joseph Dyson, Tina Riedel

Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...

WILEY2019

Anti-angiogenic immunotherapy for lung cancer

Ece Kadioglu

Lung cancer is the leading cause of cancer-associated deaths worldwide. Platinum-based chemotherapy is the most common therapeutic approach in advanced non-small cell lung cancer (NSCLC), particularly for tumors that carry non-druggable activating mutation ...

EPFL2019

A systematic review and meta-analysis of the efficacy of aortic anastomotic devices

Nikolaos Stergiopoulos, Dimitrios Schizas

Objective: One of the factors contributing to complications related to open repair of the aorta is the construction of a hand-sewn anastomosis. Aortic anastomotic devices (AADs), such as the intraluminal ringed graft (IRG), and the anastomotic stenting tec ...

MOSBY-ELSEVIER2019

Analysis of morphological and haemodynamical indexes in abdominal aortic aneurysms as preliminary indicators of intraluminal thrombus deposition

Alfio Quarteroni, Simone Deparis, Claudia Maria Colciago

In this paper we study the correlation between the Wall Shear Stress (WSS), a haemodynamical index derived from numerical simulations, and an new index MFA-ILT for the characterisation of intraluminal thrombus (ILT) in presence of abdominal aortic aneurysm ...

2020

Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet, Lydia Aslanidou, Mauro Ferraro, Goran Lovric

Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and ...

2019

Hemodynamics of Focal Versus Global Growth of Small Cerebral Aneurysms

Pierre Bouillot, Hasan Yilmaz

Background and PurposeHemodynamics play adriving role in the life cycle of brain aneurysms from initiation through growth until eventual rupture. The specific factors behind aneurysm growth, especially in small aneurysms, are not well elucidated. The goal ...

2019

How Flow Reduction Influences the Intracranial Aneurysm Occlusion: A Prospective 4D Phase-Contrast MRI Study

Mohamed Farhat, Philippe Reymond, Pierre Bouillot

BACKGROUND AND PURPOSE: Flow-diverter stents are widely used for the treatment of wide-neck intracranial aneurysms. Various parameters may influence intracranial aneurysm thrombosis, including the flow reduction induced by flow-diverter stent implantation, ...

American Society of Neuroradiology (ASNR)2019

Periostin Limits Tumor Response to VEGFA Inhibition

Ioanna Keklikoglou, Michele De Palma, Ece Kadioglu, Axel Bellotti

Resistance to antiangiogenic drugs limits their applicability in cancer therapy. Here, we show that revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are depen ...

2018

Chemo-manipulation of tumor blood vessels by a metal-based anticancer complex enhances antitumor therapy

Hubert van den Bergh, Paul Joseph Dyson, Tina Riedel

Human pleural mesothelioma is an incurable and chemoresistant cancer. Using a nude mouse xenograft model of human pleural mesothelioma, we show that RAPTA-T, a compound undergoing preclinical evaluation, enhances tumor vascular function by decreasing blood ...

Nature Research2018