Publications associées à Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization

Publications associées (35)

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

EPFL2024

Rational Design of 2D Supramolecular Networks Switchable by External Electric Fields

Radovan Vanta, Magalí Alejandra Lingenfelder, Fernando Pablo Cometto

The reversible formation of hydrogen bonds is a ubiquitous mechanism for controlling molecular assembly in biological systems. However, achieving predictable reversibility in artificial two-dimensional (2D) materials remains a significant challenge. Here, ...

Amer Chemical Soc2024

Universal Casimir attraction between filaments at the cell scale

Anne-Florence Raphaëlle Bitbol

The electromagnetic Casimir interaction between dielectric objects immersed in salted water includes a universal contribution that is not screened by the solvent and therefore long-ranged. Here, we study the geometry of two parallel dielectric cylinders. W ...

Iop Publishing Ltd2024

Amino acids modulate liquid-liquid phase separation in vitro and in vivo by regulating protein-protein interactions

Francesco Stellacci, Xufeng Xu, Laura Roset Julia

Copyright © 2024 the Author(s). Published by PNAS.Liquid-liquid phase separation (LLPS) is an intracellular process widely used by cells for many key biological functions. It occurs in complex and crowded environments, where amino acids (AAs) are vital com ...

National Academy of Sciences2024

Engineered substrates incapable of induction of chondrogenic differentiation compared to the chondrocyte imprinted substrates

Philippe Renaud, Leila Montazeri

It is well established that surface topography can affect cell functions. However, finding a reproducible and reliable method for regulating stem cell behavior is still under investigation. It has been shown that cell imprinted substrates contain micro- an ...

IOP Publishing Ltd2023

Nanomechanical Modeling of the Bending Response of Silicon Nanowires

Yusuf Leblebici, Zuhal Tasdemir

Understanding the mechanical behavior of silicon nanowiresis essentialfor the implementation of advanced nanoscale devices. Although bendingtests are predominantly used for this purpose, their findings shouldbe properly interpreted through modeling. Variou ...

AMER CHEMICAL SOC2023

How to Make Elastomers Piezoelectric?

Frank Nüesch, Francis Owusu

Piezoelectrics play a significant role in modern electronics and electric devices. Thermal or mechanical stress on such materials induces a change in polarization generating an electric response, which is the sole effect of why they are so interesting. How ...

Wiley2023

Experimental investigation of rotational behavior of pseudo-ductile adhesive angle joints exhibiting variable strain rate

Thomas Keller, Ghazaleh Eslami, Abdolvahid Movahedirad

Pseudo-ductile behavior in composite structural frames can be achieved by enabling their beam-column joints to exhibit nonlinear structural response due to progressive damage, by using pseudo-ductile adhesives. This study investigates the static behavior o ...

2023

Advancing first principle-based molecular dynamics of biological systems with machine learning

François Louis Mouvet

Molecular dynamics (MD) simulations have emerged as a transformative approach to analyse molecular systems at the atomic level, offering valuable insights into complex biological processes. Many biological phenomena can only accurately be described by inco ...

EPFL2023

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Martinus Adela Maria Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

eLIFE SCIENCES PUBL LTD2023

Effects of resonator geometry and substrate stiffness on the tunability of a deformable microwave metasurface

Romain Christophe Rémy Fleury

Tunable metasurfaces can shift their resonant frequency through different approaches, one of which is applying mechanical deformations. Here, we show the effects of two key factors on the tunability of deformable metasurfaces; the resonator geometry and su ...

2022

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

Wiley2021

On the behavior of uniaxial static stress loaded micro-scale fused silica beams at room temperature

Yves Bellouard, Christos Edouardos Athanasiou, Saood Ibni Nazir

The question of whether static stress in fused silica relaxes at room temperature is still under debate. Here, we report experimental data investigating the behavior of fused silica at room temperature when subjected to static tensile stress up to 2 GPa st ...

Elsevier2022

Development of a semi-implicit contact methodology for finite volume stress solvers

Andreas Pautz, Alessandro Scolaro, Carlo Fiorina

The past decades have seen numerous efforts to apply the finite volume methodology to solid mechanics problems. However, only limited work has been done by the finite volume community toward the simulation of mechanical contact. In this article, we present ...

Wiley2022

A Homogenization Model for Soft Magnetic Composites Considering the Effect of Mechanical Stress

Xiaotao Ren

Soft Magnetic Composites (SMC) are an alternative to laminated steels for the design of smaller and lighter electromagnetic devices.Such electromagnetic devices might be subjected to significant mechanical stresses that can alter their electromagnetic prop ...

Institute of Electrical and Electronics Engineers2022

General invariance and equilibrium conditions for lattice dynamics in 1D, 2D, and 3D materials

Nicola Marzari, Samuel Poncé, Changpeng Lin

The long-wavelength behavior of vibrational modes plays a central role in carrier transport, phonon-assisted optical properties, superconductivity, and thermomechanical and thermoelectric properties of materials. Here, we present general invariance and equ ...

NATURE PORTFOLIO2022

Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration

Hwanseok Jang

Collective cell migration of epithelial tumor cells is one of the important factors for elucidating cancer metastasis and developing novel drugs for cancer treatment. Especially, new roles of E-cadherin in cancer migration and metastasis, beyond the epithe ...

MDPI2021

Effect of Native Oxide on Stress in Silicon Nanowires: Implications for Nanoelectromechanical Systems

Yusuf Leblebici, Zuhal Tasdemir

Understanding the origins of intrinsic stress in Si nanowires (NWs) is crucial for their successful utilization as transducer building blocks in next-generation, miniaturized sensors based on nanoelectromechanical systems (NEMS). With their small size lead ...

AMER CHEMICAL SOC2022

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Christian Heinis, Jonas Alfred Karl Wilbs, Davide Bertoldo, Ganesh Kumar Mothukuri, Raphael Johannes Gübeli

Actin is the most abundant protein in eukaryotic cells and is key to many cellular functions. The filamentous form of actin (F-actin) can be studied with help of natural products that specifically recognize it, as for example fluorophore-labeled probes of ...

2021

Mechanical principles of engineering fibrous tissues with programmable shape

Erik Mailand

The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...

EPFL2021