Primate-specific transposable elements shape transcriptional networks during human development

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We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Many biological methods are based on single-cell isolation. In single-cell line development, the gold standard involves the dilution of cells by means of a pipet. This process is time-consuming as it is repeated over several weeks to ensure clonality. Here ...

Bone marrow transplantation is a well-established medical procedure for the treatment of various hematologic diseases. However, the relatively low number of hematopoietic stem cells (HSCs) that can be harvested, especially from umbilical cord blood, limits ...

A long-standing question in biology is whether multipotent somatic stem and progenitor cells (SSPCs) feature molecular properties that could guide their system-independent identification. Population-based transcriptomic studies have so far not been able to ...

Lineage tracing is a basic concept in developmental biology, as well as diseases related to organ development. A reliable method to track cell lineages in human tissues has the potential to greatly contribute to the fields of oncogenesis, tissue renewal, a ...

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps during earlydevelopment. In this review, we discuss processes that set up the embryonic axes, with an emphasis onpolarity establishment and asymmetric division. W ...

We report optimization of a serum- and feeder-free, three-dimensional (3D) niche created with a synthetic polyethylene glycol (PEG)-based extracellular matrix for self-renewal of human embryonic stem cells (hESCs). Three hESC lines (H9, H1 and Novo) were c ...

Articular cartilage regeneration poses particularly tough challenges for implementing cell-‐based therapies. Many cell types have been investigated looking for a balanced combination of responsiveness and stability, yet techniques are still far from defin ...

Motivation: Genomic context analysis, also known as phylogenetic profiling, is widely used to infer functional interactions between proteins but rarely applied to non-coding cis-regulatory DNA elements. We were wondering whether this approach could provide ...

SPINK5 (serine protease inhibitor Kazal-type 5) encodes the proteinase inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor). In skin, LEKTI expression is restricted to the stratum granulosum of the epidermis and the inner root sheath of hair fo ...

T cell development in the thymus depends on continuous colonization by hematopoietic precursors. Several distinct T cell precursors have been identified, but whether one or several independent precursor cell types maintain thymopoiesis is unclear. We have ...

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

Primate-specific transposable elements shape transcriptional networks during human development

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An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Impedance-Based Single-Cell Pipetting

Modeling hematopoietic stem cell dynamics in bioengineered niches

Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

Cell lineage tracing in human tissues using somatic mitochondrial mutations

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos

A feeder-free, defined three-dimensional polyethylene glycol-based extracellular matrix niche for culture of human embryonic stem cells

Epiphyseal chondro-progenitors provide a stable cell source for cartilage cell therapy

Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering