Publications associées à Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor- reactive CD8+T cells and reprogramming macrophages

Publications associées (6)

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Nature Portfolio2024

Comparison of linear frequency and amplitude modulation for intraneural sensory feedback in bidirectional hand prostheses

Silvestro Micera, Francesco Maria Petrini, Ivo Strauss, Stanisa Raspopovic, Giacomo Valle, Pablo Garcia del Valle, Edoardo D'Anna, Valeria Granata

Recent studies have shown that direct nerve stimulation can be used to provide sensory feedback to hand amputees. The intensity of the elicited sensations can be modulated using the amplitude or frequency of the injected stimuli. However, a comprehensive c ...

Nature Research2018

Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Edward Allen Phelps, Marcela Rincón-Restrepo, Sylvie Hauert

Nanoparticle delivery systems are known to enhance the immune response to soluble antigens (Ags) and are thus a promising tool for the development of new vaccines. Our laboratory has engineered two different nanoparticulate systems in which Ag is either en ...

Elsevier Sci Ltd2017

Cooperative Roles of SDF-1 alpha and EGF Gradients on Tumor Cell Migration Revealed by a Robust 3D Microfluidic Model

Melody Swartz

Chemokine-mediated directed tumor cell migration within a three dimensional (3D) matrix, or chemoinvasion, is an important early step in cancer metastasis. Despite its clinical importance, it is largely unknown how cytokine and growth factor gradients with ...

Public Library of Science2013

Lymphatic drainage function and its immunological implications: From dendritic cell homing to vaccine design

Jeffrey Alan Hubbell, Melody Swartz

The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic capillaries provides transport of macromolecular nutrients to cells in the interstitium. We discuss herein how this flow also provides continuous access to immune ce ...

Elsevier2008

Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells

Patrick Aebischer, Laurence Winkel

A phase I/II clinical trial has been performed in 12 amyotrophic lateral sclerosis (ALS) patients to evaluate the safety and tolerability of intrathecal implants of encapsulated genetically engineered baby hamster kidney (BHK) cells releasing human ciliary ...

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